U-Blot® TRAF3 Rabbit mAb

U-Blot® TRAF3 Rabbit mAb
U-Blot® TRAF3 Rabbit mAb
$268.00
Size:50μL
SKU: WR4982-50

Catalog No.: WR4982

Specification: 50μL/100μL

Stock: In stock

U-Blot® TRAF3 Rabbit mAb Learn more

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Product information

Product detailsSpecificationsQ & AEducation

Background：TNF receptor associated factor 3(TRAF3) Homo sapiens The protein encoded by this gene is a member of the TNF receptor associated factor (TRAF) protein family. TRAF proteins associate with, and mediate the signal transduction from, members of the TNF receptor (TNFR) superfamily. This protein participates in the signal transduction of CD40, a TNFR family member important for the activation of the immune response. This protein is found to be a critical component of the lymphotoxin-beta receptor (LTbetaR) signaling complex, which induces NF-kappaB activation and cell death initiated by LTbeta ligation. Epstein-Barr virus encoded latent infection membrane protein-1 (LMP1) can interact with this and several other members of the TRAF family, which may be essential for the oncogenic effects of LMP1. Several alternatively spliced transcript variants encoding three distinct isoforms have been reported. [provided by RefSeq, Dec 2010],

Product Overview

Catalog No.
WR4982
SKU
WR4982-50
Category
Rabbit mAbs
Product Type
Other
Size
50μL/100μL
Stock Status
In stock
Available Stock
20
Minimum Order Quantity
1

Storage & Compliance

Storage
-15°C to -25°C/1 year(Do not lower than -25°C)
Research Use Only
Yes

Additional Specifications

Target
TRAF3
Reactivity
Human,Mouse,Rat
Application
WB,IF,ELISA
MW(Calculated)
64kD
MW(Observed)
64kD
Host Species
Rabbit
Isotype
IgG,Kappa
Conjugate/Modification
Thr246
Modification site
--
Recommended Dilution Ratio
WB 1:2000-1:10000;IF 1:200-1:1000;ELISA 1:5000-1:20000;
Form
PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
Source
--
Purification
Protein A
Purity
--
storageCondition
-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration
--
Clonality
Monoclonal
Clone No.
PT1214R
Immunogen
--
Sequence
--
Specificity
Endogenous
Gene Name
TRAF3
Protein Name
TNF receptor-associated factor 3
Other Name
TRAF3;CAP1;CRAF1;TNF receptor-associated factor 3;CAP-1;CD40 receptor-associated factor 1;CRAF1;CD40-binding protein;CD40BP;LMP1-associated protein 1;LAP1
Organism-1
Human
Gene ID-1
7187
SwissProt-1
Q13114
Organism-2
Mouse
Gene ID-2
22031
SwissProt-2
Q60803
Organism-3
--
Gene ID-3
--
SwissProt-3
--
Organism-4
--
gene ID-4
--
SwissProt-4
--
Cellular Localization
Caution:The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.,Domain:The MATH/TRAF domain binds to receptor cytoplasmic domains.,Function:Adapter protein and signal transducer that links members of the tumor necrosis factor receptor family to different signaling pathways by association with the receptor cytoplasmic domain and kinases. Seems to be involved in activation of NF-kappa-B and JNK and in apoptosis. Is regulated by TANK/ITRAF which competes with TNFRSF5/CD40 for binding. Seems to play a role T-cell dependent immune responses.,similarity:Contains 1 MATH domain.,similarity:Contains 1 RING-type zinc finger.,similarity:Contains 2 TRAF-type zinc fingers.,subunit:Homotrimer (Probable). Heteromer with TRAF5 (By similarity). Binds to TNFRSF5/CD40. Associates with LTBR/TNFRSF3, TNFRSF4, TNFRSF8/CD30, TNFRSF17/BCMA and EDAR, MAP3K5, MAP3K14, and TRAF-interacting protein TRIP and TRAF and TNF receptor associated protein TTRAP. Binds to TANK/ITRAF and TRAF3IP1. Interacts with TICAM1 (By similarity). Interacts with OTUD5.,

Tech Support

ucallm

01

Documents

Datasheet, COA, SDS, and protocol files can be requested from technical support.

02

Storage & Handling

Storage
-15°C to -25°C/1 year(Do not lower than -25°C)
06

Contact Support

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Keywords:Rabbit mAbs