U-Blot® Catenin-γ Rabbit mAb

U-Blot® Catenin-γ Rabbit mAb
U-Blot® Catenin-γ Rabbit mAb
$268.00
Size:50μL
SKU: WR5003-50

Catalog No.: WR5003

Specification: 50μL/100μL

Stock: In stock

U-Blot® Catenin-γ Rabbit mAb Learn more

Product information

Background:This gene encodes a major cytoplasmic protein which is the only known constituent common to submembranous plaques of both desmosomes and intermediate junctions. This protein forms distinct complexes with cadherins and desmosomal cadherins and is a member of the catenin family since it contains a distinct repeating amino acid motif called the armadillo repeat. Mutation in this gene has been associated with Naxos disease. Alternative splicing occurs in this gene; however, not all transcripts have been fully described. [provided by RefSeq, Jul 2008],

Product Overview

Catalog No.
WR5003
SKU
WR5003-50
Category
Rabbit mAbs
Product Type
Other
Size
50μL/100μL
Stock Status
In stock
Available Stock
20
Minimum Order Quantity
1

Storage & Compliance

Storage
-15°C to -25°C/1 year(Do not lower than -25°C)
Research Use Only
Yes

Additional Specifications

Target
Catenin-γ
Reactivity
Human,Mouse,Rat
Application
WB,IHC,IF,ELISA
MW(Calculated)
82kD
MW(Observed)
82kD
Host Species
Rabbit
Isotype
IgG,Kappa
Conjugate/Modification
Unmodified
Modification site
--
Recommended Dilution Ratio
IHC 1:200-1:1000;WB 1:2000-1:10000;IF 1:200-1:1000;ELISA 1:5000-1:20000;
Form
PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
Source
--
Purification
Protein A
Purity
--
storageCondition
-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration
--
Clonality
Monoclonal
Clone No.
PT1235R
Immunogen
--
Sequence
--
Specificity
Endogenous
Gene Name
JUP
Protein Name
Junction plakoglobin
Other Name
JUP;CTNNG;DP3;Junction plakoglobin;Catenin gamma;Desmoplakin III;Desmoplakin-3
Organism-1
Human
Gene ID-1
3728
SwissProt-1
P14923
Organism-2
Mouse
Gene ID-2
16480
SwissProt-2
Q02257
Organism-3
Rat
Gene ID-3
81679
SwissProt-3
Q6P0K8
Organism-4
--
gene ID-4
--
SwissProt-4
--
Cellular Localization
Disease:Defects in JUP are the cause of familial arrhythmogenic right ventricular dysplasia type 12 (ARVD12) [MIM:611528]; also called arrhythmogenic right ventricular cardiomyopathy type 12 (ARVC12). ARVD is an autosomal dominant disease characterized by partial degeneration of the myocardium of the right ventricle, electrical instability, and sudden death. It is clinically defined by electrocardiographic and angiographic criteria; pathologic findings, replacement of ventricular myocardium with fatty and fibrous elements, preferentially involve the right ventricular free wall.,Disease:Defects in JUP are the cause of Naxos disease (NXD) [MIM:601214]. NXD is an autosomal recessive disorder combining diffuse non-epidermolytic palmoplantar keratoderma with arrhythmogenic right ventricular dysplasia/cardiomyopathy and woolly hair.,Function:Common junctional plaque protein. The membrane-associated plaques are architectural elements in an important strategic position to influence the arrangement and function of both the cytoskeleton and the cells within the tissue. The presence of plakoglobin in both the desmosomes and in the intermediate junctions suggests that it plays a central role in the structure and function of submembranous plaques.,sequence Caution:Translation N-terminally shortened.,similarity:Belongs to the beta-catenin family.,similarity:Contains 9 ARM repeats.,subcellular location:Cytoplasmic in a soluble and membrane-associated form.,subunit:Homodimer. Interacts with MUC1.,

Tech Support

ucallm

01

Documents

Datasheet, COA, SDS, and protocol files can be requested from technical support.

02

Storage & Handling

Storage
-15°C to -25°C/1 year(Do not lower than -25°C)
06

Contact Support

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Phone+(1)-866-986-9598

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Keywords:Rabbit mAbs