U-Blot® PLC γ2 (Phospho Tyr1217) Rabbit mAb

U-Blot® PLC γ2 (Phospho Tyr1217) Rabbit mAb
U-Blot® PLC γ2 (Phospho Tyr1217) Rabbit mAb
$288.00
Size:50μL
SKU: WR5100-50

Catalog No.: WR5100

Specification: 50μL/100μL

Stock: In stock

U-Blot® PLC γ2 (Phospho Tyr1217) Rabbit mAb Learn more

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Product information

Product detailsSpecificationsQ & AEducation

Background：The protein encoded by this gene is a transmembrane signaling enzyme that catalyzes the conversion of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate to 1D-myo-inositol 1,4,5-trisphosphate (IP3) and diacylglycerol (DAG) using calcium as a cofactor. IP3 and DAG are second messenger molecules important for transmitting signals from growth factor receptors and immune system receptors across the cell membrane. Mutations in this gene have been found in autoinflammation, antibody deficiency, and immune dysregulation syndrome and familial cold autoinflammatory syndrome 3. [provided by RefSeq, Mar 2014],

Product Overview

Catalog No.
WR5100
SKU
WR5100-50
Category
Rabbit mAbs
Product Type
Other
Size
50μL/100μL
Stock Status
In stock
Available Stock
20
Minimum Order Quantity
1

Storage & Compliance

Storage
-15°C to -25°C/1 year(Do not lower than -25°C)
Research Use Only
Yes

Additional Specifications

Target
PLCG2
Reactivity
Human
Application
WB,IF,ELISA
MW(Calculated)
148kD
MW(Observed)
150kD
Host Species
Rabbit
Isotype
IgG,Kappa
Conjugate/Modification
Phospho
Modification site
Tyr1217
Recommended Dilution Ratio
WB 1:500-1:2000;IF 1:200-1:1000;ELISA 1:5000-1:20000;
Form
PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
Source
--
Purification
Protein A
Purity
--
storageCondition
-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration
--
Clonality
Monoclonal
Clone No.
PT1383R
Immunogen
--
Sequence
--
Specificity
PLC γ2 (Phospho Tyr1217) Antibody detects endogenous levels of PLC γ2 protein only when phosphorylated at Y1217.The name of modified sites may be influenced by many factors, such as species (the modified site was not originally found in human samples) and the change of protein sequence (the previous protein sequence is incomplete, and the protein sequence may be prolonged with the development of protein sequencing technology). When naming, we will use the "numbers" in historical reference to keep the sites consistent with the reports. The antibody binds to the following modification sequence (lowercase letters are modification sites):FLyDT
Gene Name
PLCG2
Protein Name
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2
Other Name
PLCG2;1-phosphatidylinositol 4;5-bisphosphate phosphodiesterase gamma-2;Phosphoinositide phospholipase C-gamma-2;Phospholipase C-IV;PLC-IV;Phospholipase C-gamma-2;PLC-gamma-2
Organism-1
Human
Gene ID-1
5336
SwissProt-1
P16885
Organism-2
Mouse
Gene ID-2
234779
SwissProt-2
Q8CIH5
Organism-3
Rat
Gene ID-3
29337
SwissProt-3
P24135
Organism-4
--
gene ID-4
--
SwissProt-4
--
Cellular Localization
Catalytic activity:1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H(2)O = 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol.,cofactor:Calcium.,Function:The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. It is a crucial enzyme in transmembrane signaling.,PTM:Phosphorylated on tyrosine residues; upon ligand-induced activation of a variety of growth factor receptors and immune system receptors. Increases phospholipase activity.,similarity:Contains 1 C2 domain.,similarity:Contains 1 PH domain.,similarity:Contains 1 PI-PLC X-box domain.,similarity:Contains 1 PI-PLC Y-box domain.,similarity:Contains 1 SH3 domain.,similarity:Contains 2 SH2 domains.,

Tech Support

ucallm

01

Documents

Datasheet, COA, SDS, and protocol files can be requested from technical support.

02

Storage & Handling

Storage
-15°C to -25°C/1 year(Do not lower than -25°C)
06

Contact Support

Emailinfo@ucallmlabs.com

Phone+(1)-866-986-9598

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Keywords:Rabbit mAbs