U-Blot® HDAC5 Rabbit mAb

U-Blot® HDAC5 Rabbit mAb
U-Blot® HDAC5 Rabbit mAb
$268.00
Size:50μL
SKU: WR5136-50

Catalog No.: WR5136

Specification: 50μL/100μL

Stock: In stock

U-Blot® HDAC5 Rabbit mAb Learn more

1
Share:fx@link

Product information

Product detailsSpecificationsQ & AEducation

Background：Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to the class II histone deacetylase/acuc/apha family. It possesses histone deacetylase activity and represses transcription when tethered to a promoter. It coimmunoprecipitates only with HDAC3 family member and might form multicomplex proteins. It also interacts with myocyte enhancer factor-2 (MEF2) proteins, resulting in repression of MEF2-dependent genes. This gene is thought to be associated with colon cancer. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008],

Product Overview

Catalog No.
WR5136
SKU
WR5136-50
Category
Rabbit mAbs
Product Type
Other
Size
50μL/100μL
Stock Status
In stock
Available Stock
20
Minimum Order Quantity
1

Storage & Compliance

Storage
-15°C to -25°C/1 year(Do not lower than -25°C)
Research Use Only
Yes

Additional Specifications

Target
HDAC5
Reactivity
Human,Mouse,Rat
Application
WB,IF,IP,ELISA
MW(Calculated)
122kD
MW(Observed)
130kD
Host Species
Rabbit
Isotype
IgG,Kappa
Conjugate/Modification
Citrullination
Modification site
--
Recommended Dilution Ratio
WB 1:500-1:2000;IF 1:200-1:1000;ELISA 1:5000-1:20000;IP 1:50-1:200;
Form
PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
Source
--
Purification
Protein A
Purity
--
storageCondition
-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration
--
Clonality
Monoclonal
Clone No.
PT1361R
Immunogen
--
Sequence
--
Specificity
Endogenous
Gene Name
HDAC5
Protein Name
Histone deacetylase 5
Other Name
HDAC5;KIAA0600;Histone deacetylase 5;HD5;Antigen NY-CO-9
Organism-1
Human
Gene ID-1
10014
SwissProt-1
Q9UQL6
Organism-2
Mouse
Gene ID-2
--
SwissProt-2
Q9Z2V6
Organism-3
--
Gene ID-3
--
SwissProt-3
--
Organism-4
--
gene ID-4
--
SwissProt-4
--
Cellular Localization
Catalytic activity:Hydrolysis of an N(6)-acetyl-lysine residue of a histone to yield a deacetylated histone.,Domain:The nuclear export sequence mediates the shuttling between the nucleus and the cytoplasm.,Function:Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Involved in muscle maturation by repressing transcription of myocyte enhancer MEF2C. During muscle differentiation, it shuttles into the cytoplasm, allowing the expression of myocyte enhancer factors.,PTM:Phosphorylated by CaMK at Ser-259 and Ser-498. The phosphorylation is required for the export to the cytoplasm.,PTM:Ubiquitinated. Polyubiquitination however does not lead to its degradation.,similarity:Belongs to the histone deacetylase family. Type 2 subfamily.,subcellular location:Shuttles between the nucleus and the cytoplasm. In muscle cells, it shuttles into the cytoplasm during myocyte differentiation. The export to cytoplasm depends on the interaction with a 14-3-3 chaperone protein and is due to its phosphorylation at Ser-259 and Ser-498 by CaMK.,subunit:Interacts with AHRR (By similarity). Interacts with BCOR, HDAC7, HDAC9, CTBP1, MEF2C, NCOR2, NRIP1, PHB2 and a 14-3-3 chaperone protein. Interacts with KDM5B.,tissue specificity:Ubiquitous.,

Tech Support

ucallm

01

Documents

Datasheet, COA, SDS, and protocol files can be requested from technical support.

02

Storage & Handling

Storage
-15°C to -25°C/1 year(Do not lower than -25°C)
06

Contact Support

Emailinfo@ucallmlabs.com

Phone+(1)-866-986-9598

WeChat / IMUcallm-Tech

HoursMonday-Friday 09:00-18:00 CST

Request Technical Support
Keywords:Rabbit mAbs