- PackSize
- 50��L/100��L
- Target
- CD46, MCP, MIC10, Membrane cofactor protein, TLX, Trophoblast leukocyte common antigen
- Reactivity
- Human
- Applications
- ELISA
- Host Species
- Rabbit
- Isotype
- IgG
- Conjugate/Modification
- --
- Recommended Dilution Ratio
- --
- Composition
- 0.01M PBS pH 7.4
Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
- Purification Process
- Protein A/G purified from cell culture supernatant.
- Purity
- >95% as determined by SDS-PAGE.
- storageCondition
- Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8��C for frequent use. Store at -20 to -80��C for twelve months from the date of receipt.
- Clonality
- Monoclonal
- Clone Number
- FOR46
- Immunogen
- --
- Alias
- --
- Species
- --
- Gene ID-1
- P15529
- Uniprot
- --
- Background
- Membrane cofactor protein is a ~43 kDa protein. Acts as a cofactor for complement factor I, a serine protease which protects autologous cells against complement-mediated injury by cleaving C3b and C4b deposited on host tissue. May be involved in the fusion of the spermatozoa with the oocyte during fertilization. Also acts as a costimulatory factor for T-cells which induces the differentiation of CD4+ into T-regulatory 1 cells. T-regulatory 1 cells suppress immune responses by secreting interleukin-10, and therefore are thought to prevent autoimmunity.
- Tissue Expression
- --
- Signaling_pathway
- --
- Research Areas
- --