- PackSize
- 50��L/100��L
- Target
- MAPT, MAPTL, MTBT1, Microtubule-associated protein tau, Neurofibrillary tangle protein, PHF-tau, Paired helical filament-tau, TAU
- Reactivity
- Human
- Applications
- ELISA, DB, IF
- Host Species
- Rabbit
- Isotype
- IgG
- Conjugate/Modification
- --
- Recommended Dilution Ratio
- --
- Composition
- 0.01M PBS pH 7.4
Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
- Purification Process
- Protein A/G purified from cell culture supernatant.
- Purity
- >95% as determined by SDS-PAGE.
- storageCondition
- Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8��C for frequent use. Store at -20 to -80��C for twelve months from the date of receipt.
- Clonality
- Monoclonal
- Clone Number
- VFA2786
- Immunogen
- --
- Alias
- --
- Species
- --
- Gene ID-1
- P10636
- Uniprot
- --
- Background
- Microtubule-associated protein tau (Tau pT217) is a ~78 kDa protein. Promotes microtubule assembly and stability, and might be involved in the establishment and maintenance of neuronal polarity. The C-terminus binds axonal microtubules while the N-terminus binds neural plasma membrane components, suggesting that tau functions as a linker protein between both. Axonal polarity is predetermined by TAU/MAPT localization (in the neuronal cell) in the domain of the cell body defined by the centrosome. The short isoforms allow plasticity of the cytoskeleton whereas the longer isoforms may preferentially play a role in its stabilization.
1. Yoshida, H. et al. (2012) Journal of neurochemistry 120, 165-76.
PMID: 21985311
2. Sandberg, A. et al. (2020) Neurobiology of disease 146, 105079.
PMID: 32961270
- Tissue Expression
- --
- Signaling_pathway
- --
- Research Areas
- --