U-Blot® Rag A/B Rabbit mAb

Background：function:Involved in the RCC1/Ran-GTPase pathway. May play a direct role in a TNF-alpha signaling pathway leading to induction of cell death. May alternatively act as a cellular target for adenovirus E3-14.7K , an inhibitor of TNF-alpha functions , thereby affecting cell death. Has guanine nucleotide-binding activity but undetectable intrinsic GTPase activity. ,similarity:Belongs to the GTR/RAG GTP-binding protein family. ,subcellular location:Predominantly cytoplasmic. May shuttle between the cytoplasm and nucleus , depending on the bound nucleotide state. Colocalizes in vivo with adenovirus E3-14.7K mainly to the cytoplasm especially near the nuclear membrane and in discrete foci on or near the plasma membrane. ,subunit:Can occur as a homodimer , or form a heterodimer with RRAGC or RRAGD in a sequence-independent manner. Binds GTP. The GTP-bound form of RRAGA interacts with NOL8. Interacts with adenovirus E3 14.7 kDa protein. ,tissue specificity:Ubiquitously expressed with highest levels of expression in skeletal muscle , heart , and brain. ,