U-Blot® CUL 2 Rabbit mAb

Background：function:Core component of multiple cullin-RING-based ECS (ElonginB/C-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complexes , which mediate the ubiquitination of target proteins. May serve as a rigid scaffold in the complex and may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The E3 ubiquitin-protein ligase activity of the complex is dependent on the neddylation of the cullin subunit and is inhibited by the association of the deneddylated cullin subunit with TIP120A/CAND1 (By similarity) . The functional specificity of the ECS complex depends on the substrate recognition component. ECS (VHL) mediates the ubiquitination of hypoxia-inducible factor (HIF) . ,pathway:Protein modification; protein ubiquitination. ,PTM:CBC (VHL) complex formation seems to promote neddylation. Deneddylated via its interaction with the COP9 signalosome (CSN) complex. ,similarity:Belongs to the cullin family. ,subunit:Component of multiple ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complexes formed of CUL2 , Elongin BC (TCEB1 and TCEB2) , RBX1 and a variable substrate-specific adapter. Component of the ECS (VHL) or CBC (VHL) complex containing VHL. Component of the ECS (MED8) complex with the probable substrate recognition component MED8 (By similarity) . Component of the ECS (PPIL5) complex with the probable substrate recognition component PPIL5. Component of a probable ECS E3 ubiquitin-protein ligase complex containing CUL2 , RBX1 , TCEB1 , TCEB2 and FEM1B. Part of an E3 ubiquitin-protein ligase complex including ZYG11B , CUL2 and Elongin BC. Part of an E3 ubiquitin-protein ligase complex including ZYG11BL , CUL2 and Elongin BC.Interacts with RBX1 , RNF7 , FEM1B and TIP120A/CAND1. Interacts with COPS2 , and MED8 (By similarity) . Interacts with human respiratory syncytial virus (HRSV) protein NS1. ,