U-Blot® FA10 Rabbit mAb

Background：catalytic activity:Selective cleavage of Arg-|-Thr and then Arg-|-Ile bonds in prothrombin to form thrombin. ,function:Factor Xa is a vitamin K-dependent glycoprotein that converts prothrombin to thrombin in the presence of factor Va , calcium and phospholipid during blood clotting. ,online information:Factor X entry ,PTM:N- and O-glycosylated. ,PTM:The activation peptide is cleaved by factor IXa (in the intrinsic pathway) , or by factor VIIa (in the extrinsic pathway) . ,PTM:The iron and 2-oxoglutarate dependent 3-hydroxylation of aspartate and asparagine is (R) stereospecific within EGF domains. ,PTM:The vitamin K-dependent , enzymatic carboxylation of some glutamate residues allows the modified protein to bind calcium. ,similarity:Belongs to the peptidase S1 family. ,similarity:Contains 1 Gla (gamma-carboxy-glutamate) domain. ,similarity:Contains 1 peptidase S1 domain. ,similarity:Contains 2 EGF-like domains. ,subunit:The two chains are formed from a single-chain precursor by the excision of two Arg residues and are held together by 1 or more disulfide bonds. ,tissue specificity:Plasma; synthesized in the liver. ,