U-Blot® RARβ Rabbit mAb

Background：This gene encodes retinoic acid receptor beta , a member of the thyroid-steroid hormone receptor superfamily of nuclear transcriptional regulators. This receptor localizes to the cytoplasm and to subnuclear compartments. It binds retinoic acid , the biologically active form of vitamin A which mediates cellular signalling in embryonic morphogenesis , cell growth and differentiation. It is thought that this protein limits growth of many cell types by regulating gene expression. The gene was first identified in a hepatocellular carcinoma where it flanks a hepatitis B virus integration site. Alternate promoter usage and differential splicing result in multiple transcript variants. [provided by RefSeq , Mar 2014] ,