U-Blot® CD68 Rabbit mAb (Ready to Use)

Background：This gene encodes a 110-kD transmembrane glycoprotein that is highly expressed by human monocytes and tissue macrophages. It is a member ofThe lysosomal/endosomal-associated membrane glycoprotein (LAMP) family.The protein primarily localizes to lysosomes and endosomes with a smaller fraction circulating toThe cell surface. It is a type I integral membrane protein with a heavily glycosylated extracellular domain and binds to tissue- and organ-specific lectins or selectins.The protein is also a member ofThe scavenger receptor family. Scavenger receptors typically function to clear cellular debris, promote phagocytosis, and mediateThe recruitment and activation of macrophages. Alternative splicing results in multiple transcripts encoding different isoforms. [provided by RefSeq, Jul 2008],