- Antibody Type
- Polyclonal
- Target
- L-Lactyllysine
- Reactivity
- Human, Rat
- Application
- WB, IHC-P
- MW(Calculated)
- Multiple
- MW(Observed)
- Multiple
- Host Species
- Rabbit
- Isotype
- IgG
- Conjugate
- Unconjugated
- Modification
- Lysine lactylation
- Modification Site
- Lys(K)
- Recommended dilution ratio
- WB 1:500-1:1000;IHC-P 1:1000-1:6000
- Composition
- PBS
- Purification process
- Protein A and antigen purified
- storageCondition
- Upon delivery centrifugate. Reconstitute with 100 μL distilled water (1.0 mg/mL after restoration). Aliquot and store at -80 °C. Avoid freeze / thaw cycles.
- Stability
- Stable for 12 months from date of receipt / reconstitution.
- Concentration
- --
- Clonal
- Polyclonal
- Clone Number
- --
- Immunogen
- polypeptide
- Gene Name
- --
- Protein Name
- --
- Alternative name
- KL-la
- Organism-1
- --
- Gene ID
- --
- SwissProt-1
- --
- --
- Background:
- Background
- L-Lactyllysine (abbreviated as Kla) is a novel lysine acylation-type post-translational modification. It is formed by the covalent attachment of an L-lactyl group to lysine residues, mainly mediated by lactoyl-CoA. Kla is widely distributed on both histone and non-histone proteins, and participates in chromatin remodeling, gene transcription regulation, cellular metabolism, and inflammatory responses. Studies have shown that L-lactylation is closely associated with tumor metabolic reprogramming, hypoxia stress, immune regulation, and various disease processes, serving as a key mechanism linking cellular metabolism and epigenetic regulation.
- Cellular Localization
- --
- --
- Background:L-Lactyllysine (abbreviated as Kla) is a novel lysine acylation-type post-translational modification. It is formed by the covalent attachment of an L-lactyl group to lysine residues, mainly mediated by lactoyl-CoA. Kla is widely distributed on both histone and non-histone proteins, and participates in chromatin remodeling, gene transcription regulation, cellular metabolism, and inflammatory responses. Studies have shown that L-lactylation is closely associated with tumor metabolic reprogramming, hypoxia stress, immune regulation, and various disease processes, serving as a key mechanism linking cellular metabolism and epigenetic regulation.
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