U-Blot® Pan-Di-Methyllysine Rabbit mAb

Background：Di-Methyllysine (Kme2) is a crucial reversible post-translational modification of proteins, which occurs on the ε-amino group of lysine residues, including symmetric and asymmetric dimethylation forms. It is widely distributed in histones and non-histone proteins, and participates in regulating chromatin remodeling, gene transcription, RNA splicing, DNA damage repair, cell cycle progression and signal transduction. Aberrant lysine dimethylation is closely associated with tumorigenesis, inflammation, neurodegeneration and metabolic disorders, serving as a vital biomarker for epigenetic and pathological research.