U-Blot® ERBB3(HER3) hIgG1 Reference Antibody (Patribio)

Background:Receptor tyrosine-protein kinase erbB-3, also known as HER3 (human epidermal growth factor receptor 3), is a membrane bound protein that in humans is encoded by the ERBB3 gene. During human development, ERBB3 is expressed in skin, bone, muscle, nervous system, heart, lungs, and intestinal epithelium.ERBB3 is expressed in normal adult human gastrointestinal tract, reproductive system, skin, nervous system, urinary tract, and endocrine system. ErbB3 is associated with targeted therapeutic resistance in numerous cancers including resistance to: HER2 inhibitors in HER2+ breast cancers; anti-estrogen therapy in ER+ breast cancers; EGFR inhibitors in lung and head and neck cancers; hormones in prostate cancers IGF1R inhibitors in hepatomas; BRAF inhibitors in melanoma. ErbB2 overexpression may promote the formation of active heterodimers with ErbB3 and other ErbB family members without the need for ligand binding, resulting in weak but constitutive signaling activity.