U-Blot® CD3E×BCMA hIgG4 Reference Antibody (Tecbio)

Background:Teclistamab is a Bispecific monoclonal antibody that enhances the immune system's ability to attack cancer cells by targeting two different antigens at once. It specifically binds to B cell maturation antigen (BCMA) and CD3 molecules on the surface of T cells, forming a“Bridge” that enables T cells to recognize and contact myeloma cells more efficiently. When Teclistamab binds to CD3, it activates T cells, prompting them to release cytokines that mediate the killing of tumor cells and thus promote their death. In addition, Teclistamab directs T cells to the tumor microenvironment, further enhancing the body's anti-tumor immune response. This mechanism dramatically improves the effectiveness of Teclistamab in treating multiple myeloma.