U-Blot® APRIL hIgG2 Reference Antibody (Sibebio)

Background:APRIL is a type II TNF superfamily membrane protein encoded by TNFSF13 (also TNFSF13A). It is expressed in various immune and some non-hematopoietic cells. It exists in membrane-bound and soluble forms (soluble via shedding). APRIL promotes B cell survival, maturation, differentiation, and immunoglobulin production; its dysregulation is linked to autoimmunity and certain hematologic cancers. APRIL binds primarily to TACI and BCMA receptors, activating canonical and noncanonical NF-κB and MAPK pathways. This upregulates anti-apoptotic genes (e.g., BCL2 family) and plasma cell differentiation factors, supporting long-lasting humoral responses. APRIL can cooperate with BAFF to modulate signaling. Dysregulated APRIL–receptor signaling is associated with autoimmunity, making it a therapeutic target in diseases like SLE and monoclonal gammopathies.