U-Blot® CLDN1 hIgG1 Reference Antibody (Lixubio)

Background:CLDN1(Claudin-1) is an important component of cell-cell junctions. It belongs to the cell adhesion protein family and is mainly expressed in epithelial cells. Claudin-1 is expressed in many types of epithelial cells and plays a key role in regulating cell permeability and establishing biological barriers. It plays a key role in maintaining the barrier function of cells and participating in cell signal transduction. Lixudebart is a humanized IgG1 monoclonal antibody developed by Alentis Therapeutics that targets the Claudin-1 protein and is used to treat diseases such as kidney, liver and lung fibrosis. In the treatment of ANCA-associated vasculitis and other fibrosis-related diseases, it can be used as an emerging targeted therapy in combination with traditional drugs to optimize the treatment effect.