U-Blot® CD19 Rat IgG2a Antibody

Background:The CD19 gene is located on the short arm of human chromosome 16 and encodes a type I transmembrane glycoprotein of approximately 95 kda, which belongs to the immunoglobulin superfamily. It acts as a core marker of B cells and is stably expressed from early precursor B cell to mature B cell stages, but is turned off upon plasma cell differentiation. CD19 forms a co-receptor complex with CD21 and CD81, which regulates B cell development, proliferation and antibody production by lowering the B cell receptor activation threshold. Mutations in this gene cause a common variable immunodeficiency disease (CVID3) , characterized by reduced antibody production and recurrent infections. Because of its high specificity and wide expression in B cell malignancies, CD19 has become a key target for immunotherapy such as CAR-T therapy and bispecific monoclonal antibody.