U-Blot® LIN28A mouse mAb

Name: U-Blot® LIN28A mouse mAb
SKU: WM0671
Availability: InStock

$268.00

Size:50μL

SKU: WM0671-50

Catalog No.: WM0671

Specification: 50μL/100μL

Stock: In stock

U-Blot® LIN28A mouse mAb Learn more

Product details Specifications Q & A Education

Background：This gene encodes a LIN-28 family RNA-binding protein that acts as a posttranscriptional regulator of genes involved in developmental timing and self-renewal in embryonic stem cells. The encoded protein functions through direct interaction with target mRNAs and by disrupting the maturation of certain miRNAs involved in embryonic development. This protein prevents the terminal processing of the LET7 family of microRNAs which are major regulators of cellular growth and differentiation. Aberrant expression of this gene is associated with cancer progression in multiple tissues. [provided by RefSeq, Sep 2015],

Product Overview

Catalog No.: WM0671
SKU: WM0671-50
Category: Mouse mAbs
Product Type: Other
Size: 50μL/100μL
Stock Status: In stock
Available Stock: 20
Minimum Order Quantity: 1

Storage & Compliance

Storage: -15°C to -25°C/1 year(Do not lower than -25°C)
Research Use Only: Yes

Additional Specifications

Target: LIN28A
Reactivity: Human,Mouse
Application: WB
MW(Calculated): --
MW(Observed): 26kD
Host Species: Mouse
Isotype: --
Conjugate/Modification: Unmodified
Modification site: --
Recommended Dilution Ratio: WB 1:1000
Form: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Source: --
Purification: The antibody was affinity-purified from mouse ascites by affinity-chromatography using epitope-specific immunogen.
Purity: --
storageCondition: -15°C to -25°C/1 year(Do not lower than -25°C)
Concentration: --
Clonality: Monoclonal
Clone No.: --
Immunogen: Purified recombinant human LIN28A protein fragments expressed in E.coli
Sequence: --
Specificity: This antibody detects endogenous levels of LIN28A and does not cross-react with related proteins.
Gene Name: lin28a
Protein Name: Protein lin-28 homolog A
Other Name: CSDD1;FLJ12457;LIN 28;Lin-28A;LIN28;LIN28A;LN28A_HUMAN;Protein lin-28 homolog A;ZCCHC1;Zinc finger CCHC domain-containing protein 1.
Organism-1: Human
Gene ID-1: 79727
SwissProt-1: Q9H9Z2
Organism-2: Mouse
Gene ID-2: --
SwissProt-2: Q8K3Y3
Organism-3: --
Gene ID-3: --
SwissProt-3: --
Organism-4: --
gene ID-4: --
SwissProt-4: --
Cellular Localization: Cytoplasm . Rough endoplasmic reticulum . Cytoplasm, P-body . Cytoplasm, Stress granule . Nucleus, nucleolus . Predominantly cytoplasmic (PubMed:22118463). In the cytoplasm, localizes to peri-endoplasmic reticulum regions and detected in the microsomal fraction derived from rough endoplasmic reticulum (RER) following subcellular fractionation. May be bound to the cytosolic surface of RER on which ER-associated mRNAs are translated (By similarity). Shuttle from the nucleus to the cytoplasm requires RNA-binding (PubMed:17617744). Nucleolar localization is observed in 10-15% of the nuclei in differentiated myotubes (By similarity). .