U-Blot® Suz12 Monoclonal Antibody

Background:Suz12 (Suppressor-of-Zeste 12 protein, also designated as ChET9, JJAZ1 protein) is a component of the Polycomb group complexes 2, 3 and 4 ( PRC2 , PRC3 and PRC4), which also contain the histone methyltransferase EZH2 , EED (Embryonic Ectoderm Development protein) protein and the histone-binding proteins RbAP46 and RbAP48 . PRC2 is responsible for di- and trimethylation of histone 3 at lysine 27 ( Histone H3K27me2 and Histone H3K27me3 ), which leads to transcriptional repression of the target genes. Suz12 is a nuclear protein belonging to the VEFS family. Suz12 contains a zinc-finger binding motif and a VEFS box, which is required for the interaction between Suz12 and EZH2.