U-Blot® PCNA mouse mAb

Name: U-Blot® PCNA mouse mAb
SKU: WM0689
Availability: InStock

$268.00

Size:50μL

SKU: WM0689-50

Catalog No.: WM0689

Specification: 50μL/100μL

Stock: In stock

U-Blot® PCNA mouse mAb Learn more

Product details Specifications Q & A Education

Background：The protein encoded by this gene is found in the nucleus and is a cofactor of DNA polymerase delta. The encoded protein acts as a homotrimer and helps increase the processivity of leading strand synthesis during DNA replication. In response to DNA damage, this protein is ubiquitinated and is involved in the RAD6-dependent DNA repair pathway. Two transcript variants encoding the same protein have been found for this gene. Pseudogenes of this gene have been described on chromosome 4 and on the X chromosome. [provided by RefSeq, Jul 2008],

Product Overview

Catalog No.: WM0689
SKU: WM0689-50
Category: Mouse mAbs
Product Type: Other
Size: 50μL/100μL
Stock Status: In stock
Available Stock: 20
Minimum Order Quantity: 1

Storage & Compliance

Storage: -15°C to -25°C/1 year(Do not lower than -25°C)
Research Use Only: Yes

Additional Specifications

Target: PCNA
Reactivity: Human,Mouse,Monkey,Rat,Hamster
Application: WB,IP,ICC,IHC
MW(Calculated): --
MW(Observed): 30-33kD
Host Species: Mouse
Isotype: --
Conjugate/Modification: Unmodified
Modification site: --
Recommended Dilution Ratio: WB 1:1000;ICC 1:100
Form: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Source: --
Purification: The antibody was affinity-purified from mouse ascites by affinity-chromatography using epitope-specific immunogen.
Purity: --
storageCondition: -15°C to -25°C/1 year(Do not lower than -25°C)
Concentration: --
Clonality: Monoclonal
Clone No.: --
Immunogen: Purified recombinant human PCNA protein fragments expressed in E.coli.
Sequence: --
Specificity: This antibody detects endogenous levels of PCNA and does not cross-react with related proteins.
Gene Name: pcna
Protein Name: Proliferating cell nuclear antigen
Other Name: Cyclin;DNA polymerase delta auxiliary protein;HGCN8729;MGC8367;Mutagen-sensitive 209 protein;OTTHUMP00000030189;OTTHUMP00000030190;PCNA;Pcna/cyclin;PCNA_HUMAN;PCNAR;Polymerase delta accessory protein;Proliferating Cell Nuclear Antigen.
Organism-1: Human
Gene ID-1: 5111
SwissProt-1: P12004
Organism-2: Mouse
Gene ID-2: --
SwissProt-2: P17918
Organism-3: --
Gene ID-3: --
SwissProt-3: --
Organism-4: --
gene ID-4: --
SwissProt-4: --
Cellular Localization: Nucleus . Colocalizes with CREBBP, EP300 and POLD1 to sites of DNA damage (PubMed:24939902). Forms nuclear foci representing sites of ongoing DNA replication and vary in morphology and number during S phase (PubMed:15543136). Co-localizes with SMARCA5/SNF2H and BAZ1B/WSTF at replication foci during S phase (PubMed:15543136). Together with APEX2, is redistributed in discrete nuclear foci in presence of oxidative DNA damaging agents. .