U-Blot® EGF Receptor mouse mAb

Name: U-Blot® EGF Receptor mouse mAb
SKU: WM0704
Availability: InStock

$268.00

Size:50μL

SKU: WM0704-50

Catalog No.: WM0704

Specification: 50μL/100μL

Stock: In stock

U-Blot® EGF Receptor mouse mAb Learn more

Product details Specifications Q & A Education

Background：The protein encoded by this gene is a transmembrane glycoprotein that is a member of the protein kinase superfamily. This protein is a receptor for members of the epidermal growth factor family. EGFR is a cell surface protein that binds to epidermal growth factor. Binding of the protein to a ligand induces receptor dimerization and tyrosine autophosphorylation and leads to cell proliferation. Mutations in this gene are associated with lung cancer. [provided by RefSeq, Jun 2016],

Product Overview

Catalog No.: WM0704
SKU: WM0704-50
Category: Mouse mAbs
Product Type: Other
Size: 50μL/100μL
Stock Status: In stock
Available Stock: 20
Minimum Order Quantity: 1

Storage & Compliance

Storage: -15°C to -25°C/1 year(Do not lower than -25°C)
Research Use Only: Yes

Additional Specifications

Target: EGFR
Reactivity: Human,Monkey
Application: WB,IHC,ICC,IP
MW(Calculated): --
MW(Observed): 175kD
Host Species: Mouse
Isotype: --
Conjugate/Modification: Unmodified
Modification site: --
Recommended Dilution Ratio: WB 1:500-1:2000;IHC 1:100-1:300;IF 1:200-1:1000;ELISA 1:5000;IP 1:50-100
Form: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Source: --
Purification: The antibody was affinity-purified from mouse ascites by affinity-chromatography using epitope-specific immunogen.
Purity: --
storageCondition: -15°C to -25°C/1 year(Do not lower than -25°C)
Concentration: --
Clonality: Monoclonal
Clone No.: --
Immunogen: Purified recombinant human EGFR protein fragments expressed in E.coli.
Sequence: --
Specificity: The antibody detects endogenous level of total EGFR and does not cross-react with related proteins.
Gene Name: egfr
Protein Name: Epidermal growth factor receptor
Other Name: Avian erythroblastic leukemia viral;v erb b;oncogene homolog;Cell growth inhibiting protein 40;Cell proliferation inducing protein 61;EGF R;EGFR;EGFR_HUMAN;Epidermal growth factor receptor;avian erythroblastic leukemia viral;v erb b;oncogene homolog;Epidermal growth factor receptor;erythroblastic leukemia viral;v erb b;oncogene homolog avian;Epidermal growth factor receptor;erbb 1;Erbb;Erbb1;ERBB1;Errp;HER1;mENA;Oncogene ERBB;PIG61;Proto-oncogene c-ErbB-1;Receptor tyrosine protein kinase ErbB 1;Receptor tyrosine-protein kinase ErbB-1;Urogastrone;wa2;Wa5.
Organism-1: Human
Gene ID-1: 1956
SwissProt-1: P00533
Organism-2: Mouse
Gene ID-2: --
SwissProt-2: Q01279
Organism-3: --
Gene ID-3: --
SwissProt-3: --
Organism-4: --
gene ID-4: --
SwissProt-4: --
Cellular Localization: Cell membrane ; Single-pass type I membrane protein . Endoplasmic reticulum membrane ; Single-pass type I membrane protein. Golgi apparatus membrane; Single-pass type I membrane protein. Nucleus membrane; Single-pass type I membrane protein. Endosome . Endosome membrane. Nucleus . In response to EGF, translocated from the cell membrane to the nucleus via Golgi and ER (PubMed:20674546, PubMed:17909029). Endocytosed upon activation by ligand (PubMed:2790960, PubMed:17182860, PubMed:27153536, PubMed:17909029). Colocalized with GPER1 in the nucleus of estrogen agonist-induced cancer-associated fibroblasts (CAF) (PubMed:20551055). .; [Isoform 2]: Secreted.