U-Blot® SIRT1 mouse mAb

Name: U-Blot® SIRT1 mouse mAb
SKU: WM0712
Availability: InStock

$268.00

Size:50μL

SKU: WM0712-50

Catalog No.: WM0712

Specification: 50μL/100μL

Stock: In stock

U-Blot® SIRT1 mouse mAb Learn more

Product details Specifications Q & A Education

Background：This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class I of the sirtuin family. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2008],

Product Overview

Catalog No.: WM0712
SKU: WM0712-50
Category: Mouse mAbs
Product Type: Other
Size: 50μL/100μL
Stock Status: In stock
Available Stock: 20
Minimum Order Quantity: 1

Storage & Compliance

Storage: -15°C to -25°C/1 year(Do not lower than -25°C)
Research Use Only: Yes

Additional Specifications

Target: SIRT1
Reactivity: Human
Application: WB,IP
MW(Calculated): --
MW(Observed): 85-110kD
Host Species: Mouse
Isotype: --
Conjugate/Modification: Unmodified
Modification site: --
Recommended Dilution Ratio: WB 1:1000
Form: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Source: --
Purification: The antibody was affinity-purified from mouse ascites by affinity-chromatography using epitope-specific immunogen.
Purity: --
storageCondition: -15°C to -25°C/1 year(Do not lower than -25°C)
Concentration: --
Clonality: Monoclonal
Clone No.: --
Immunogen: Purified recombinant human SIRT1 protein fragments expressed in E.coli.
Sequence: --
Specificity: This antibody detects endogenous levels of SIRT1 and does not cross-react with related proteins.
Gene Name: sirt1
Protein Name: --
Other Name: 75SirT1;BA57G10.4;BA57G10.4;hSIR2;hSIRT1;HST2, S. cerevisiae, homolog of;NAD dependent deacetylase SIRT1;NAD dependent deacetylase sirtuin 1;NAD dependent protein deacetylase sirtuin 1;OTTHUMP00000198111;OTTHUMP00000198112;Regulatory protein SIR2 homolog 1;SIR1_HUMAN;SIR2 like 1;SIR2 like protein 1;SIR2, S.cerevisiae, homolog-like 1;SIR2-like protein 1;SIR2ALPHA;SIR2ALPHA;SIR2alpha protein;SIR2alpha protein;SIR2L1;SIRT 1;Sirt1;SIRT1 Sir2 like proteins;siruitins;type 1;SIRT1: sirtuin;silent mating type information regulation 2 homolog;1;S. cerevisiae;SIRT1: sirtuin;silent mating type information regulation 2 homolog;1;S. cerevisiae;SirtT1 75 kDa fragment;sirtuin;silent mating type information regulation 2 homolog;1;S. cerevisiae;Sirtuin 1;sirtuin;Sirtuin type 1;Sirtuin type 1.
Organism-1: Human
Gene ID-1: 23411
SwissProt-1: Q96EB6
Organism-2: Mouse
Gene ID-2: --
SwissProt-2: Q923E4
Organism-3: --
Gene ID-3: --
SwissProt-3: --
Organism-4: --
gene ID-4: --
SwissProt-4: --
Cellular Localization: Nucleus, PML body . Cytoplasm . Nucleus . Recruited to the nuclear bodies via its interaction with PML (PubMed:12006491). Colocalized with APEX1 in the nucleus (PubMed:19934257). May be found in nucleolus, nuclear euchromatin, heterochromatin and inner membrane (PubMed:15469825). Shuttles between nucleus and cytoplasm (By similarity). Colocalizes in the nucleus with XBP1 isoform 2 (PubMed:20955178). .; [SirtT1 75 kDa fragment]: Cytoplasm . Mitochondrion .