- Target
- STAT3
- Reactivity
- Human, Mouse
- Applications
- WB,ICC, ChIP,
- MW(Calculated)
- --
- Host Species
- Mouse
- Isotype
- Mouse IgG1, κ
- Recommended Dilution Ratio
- Each lot of this antibody is quality control tested by Western blotting . For Western blotting, the suggested use of this reagent is 0.5 - 1.0 µg per ml (1:500 - 1:1000 dilution). For immunocytochemistry, a concentration of 0.5 μg/ml is recommended. For ChIP applications, the suggested dilution is 1:50 by volume. It is recommended that the reagent be titrated for optimal performance for each application.
- Formulation
- This antibody is provided in phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide. Previous lots of this product may have been formulated with 0.1% or 0.05% NaN 3 instead of 0.09% NaN 3 . For further information please contact BioLegend Technical Support or Customer Service .
- Purification
- The antibody was purified by affinity chromatography.
- Storage
- Upon receipt, store undiluted between 2°C and 8°C.
- Concentration
- 0.5 mg/ml
- Clonality
- Monoclonal
- Clone Number
- 13A3-1
- Immunogen
- KLH conjugated modified synthetic peptide
- Specificity
- STAT3 Phospho Tyr705
- Gene Name
- --
- Other Name
- Signal transducer and activator of transcription 3, Acute-phase response factor, APRF, HIES
- Gene ID
- 6774
- Cellular Localization
- Phospho-Proteins
- Function
- STAT3 is tyrosine phosphorylated by receptor kinases in response to a variety of cytokines and growth factors. It forms homo- or heterodimer with STAT1 when tyrosine is phosphorylated, and then translocates to nucleus, acting as a transcription regulator. It is also essential for the differentiation of TH17 cells, which is involved in autoimmune diseases.