U-Blot® Pan Phospho-4E-BP1 (Thr37/46) Rabbit mAb

U-Blot® Pan Phospho-4E-BP1 (Thr37/46) Rabbit mAb
U-Blot® Pan Phospho-4E-BP1 (Thr37/46) Rabbit mAb
$288.00
Size:100μl
SKU: WT9057-100

Catalog No.: WT9057

Specification: 100μL/300μL

Stock: In stock

Product details, specifications, documents, and related products are available from the catalog record. Learn more

1
Share:fx@link

Product information

Product detailsSpecificationsQ & AEducation

Background：Eukaryotic translation initiation factor 4E-binding protein 1 (4E-BP1) is a repressor of translation initiation that regulates EIF4E activity by preventing its assembly into the eIF4F complex. The 4E-BP1 hypophosphorylated form competes with EIF4G1/EIF4G3 and strongly binds to EIF4E, leading to repress translation. In contrast, hyperphosphorylated form dissociates from EIF4E, allowing interaction between EIF4G1/EIF4G3 and EIF4E, leading to initiation of translation. Besides, 4E-BP1 mediates the regulation of protein translation by hormones, growth factors and other stimuli that signal through the MAP kinase and mTORC1 pathways.

Product Overview

Catalog No.
WT9057
SKU
WT9057-100
Category
Phosphorylation
Product Type
Other
Size
100μL/300μL
Stock Status
In stock
Available Stock
20
Minimum Order Quantity
1

Storage & Compliance

Storage
Store at -20°C. Avoid repeated freeze-thaw cycles
Research Use Only
Yes

Additional Specifications

Antibody Type
Recombinant monoclonal
Target
Phospho-4E-BP1 (Thr37/46)
Reactivity
Human
Application
WB
MW(Calculated)
13 kDa
MW(Observed)
15 kDa
Host Species
Rabbit
Isotype
IgG
Conjugate
Unconjugated
Modification
Phosphorylation
Modification Site
Thr37/46
Recommended dilution ratio
WB 1:500-1:1000
Composition
PBS, Glycerol, BSA
Purification process
Protein A affinity purification
storageCondition
Store at -20°C. Avoid repeated freeze-thaw cycles
Stability
Stable for 12 months from date of receipt / reconstitution.
Concentration
--
Clonal
Recombinant monoclonal
Clone Number
W-R32
Immunogen
polypeptide
Gene Name
EIF4EBP1
Protein Name
Eukaryotic translation initiation factor 4E-binding protein 1
Alternative name
4E-BP1, PHAS-I
Organism-1
Human
Gene ID
1978
SwissProt-1
Q13541
--
Background：
Background
Eukaryotic translation initiation factor 4E-binding protein 1 (4E-BP1) is a repressor of translation initiation that regulates EIF4E activity by preventing its assembly into the eIF4F complex. The 4E-BP1 hypophosphorylated form competes with EIF4G1/EIF4G3 and strongly binds to EIF4E, leading to repress translation. In contrast, hyperphosphorylated form dissociates from EIF4E, allowing interaction between EIF4G1/EIF4G3 and EIF4E, leading to initiation of translation. Besides, 4E-BP1 mediates the regulation of protein translation by hormones, growth factors and other stimuli that signal through the MAP kinase and mTORC1 pathways.
Cellular Localization
Cytoplasm, Nucleus
--
Background：Eukaryotic translation initiation factor 4E-binding protein 1 (4E-BP1) is a repressor of translation initiation that regulates EIF4E activity by preventing its assembly into the eIF4F complex. The 4E-BP1 hypophosphorylated form competes with EIF4G1/EIF4G3 and strongly binds to EIF4E, leading to repress translation. In contrast, hyperphosphorylated form dissociates from EIF4E, allowing interaction between EIF4G1/EIF4G3 and EIF4E, leading to initiation of translation. Besides, 4E-BP1 mediates the regulation of protein translation by hormones, growth factors and other stimuli that signal through the MAP kinase and mTORC1 pathways.
--
--
--
--
--
--
--
--
--
--
--
--

Tech Support

ucallm

01

Documents

Datasheet, COA, SDS, and protocol files can be requested from technical support.

02

Storage & Handling

Storage
Store at -20°C. Avoid repeated freeze-thaw cycles
06

Contact Support

Emailinfo@mail.ucallm.com

Phone+(1)-866-986-9598

WeChat / IMUcallm-Tech

HoursMonday-Friday 09:00-18:00 CST

Request Technical Support
Keywords:Phosphorylation