- Antibody Type
- Recombinant monoclonal
- Target
- Phospho-GAP43 (Ser41)
- Reactivity
- Human
- Application
- WB
- MW(Calculated)
- 25 kDa
- MW(Observed)
- 50 kDa
- Host Species
- Rabbit
- Isotype
- IgG
- Conjugate
- Unconjugated
- Modification
- Phosphorylation
- Modification Site
- Ser41
- Recommended dilution ratio
- WB 1:2000-1:5000
- Composition
- PBS, Glycerol, BSA
- Purification process
- Protein A affinity purification
- storageCondition
- Store at -20°C. Avoid repeated freeze-thaw cycles
- Stability
- Stable for 12 months from date of receipt / reconstitution.
- Concentration
- --
- Clonal
- Recombinant monoclonal
- Clone Number
- W-R44
- Immunogen
- polypeptide
- Gene Name
- GAP43
- Protein Name
- Growth-associated protein 43
- Alternative name
- Axonal membrane protein GAP-43
- Organism-1
- Human
- Gene ID
- 2596
- SwissProt-1
- P17677
- --
- Background:
- Background
- GAP43, also known as neurotrophic factor, B-50, P-57, F1, and pp46, is a neuron growth-related protein. It is primarily enriched in growth cones and regions of high plasticity. In addition, GAP43 is one of the important substrates of protein kinase C (PKC) in the brain. PKC can phosphorylate the Ser41 site of GAP43. This phosphorylation process is regulated by intracellular Ca2+ concentration and affects the binding ability of GAP43 with calmodulin. This regulatory process plays a critical role in neuronal growth, synapse formation, and cortical development.
- Cellular Localization
- Cytoplasm, Cell Membrane, Cell projection
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- Background:GAP43, also known as neurotrophic factor, B-50, P-57, F1, and pp46, is a neuron growth-related protein. It is primarily enriched in growth cones and regions of high plasticity. In addition, GAP43 is one of the important substrates of protein kinase C (PKC) in the brain. PKC can phosphorylate the Ser41 site of GAP43. This phosphorylation process is regulated by intracellular Ca2+ concentration and affects the binding ability of GAP43 with calmodulin. This regulatory process plays a critical role in neuronal growth, synapse formation, and cortical development.
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