Tyrosine Nitration (3-Nitrotyrosine)

Introduction

Protein tyrosine nitration is a non‑enzymatic PTM triggered by reactive nitrogen species (RNS) under oxidative and inflammatory conditions. This modification results in the formation of 3‑nitrotyrosine through the addition of a nitro group (-NO₂) to tyrosine residues, altering protein structure and function. Tyrosine nitration is recognized as a marker of nitrosative stress and has been implicated in inflammation, aging, and chronic diseases.

Products Solutions

Our tyrosine nitration products include 3‑nitrotyrosine‑specific antibodies, motif enrichment reagents, and human protein nitration arrays, supporting modification detection, enrichment, and high‑throughput profiling.

• Specific recognition of 3‑nitrotyrosine
• MultiPTM antibody mix for improved detection efficiency
• Motif enrichment kit for 3‑nitrotyrosine profiling
• Protein arrays for high‑throughput tyrosine nitration analysis

Product List

Research Areas

• Oxidative stress and inflammation
• Neurodegenerative diseases
• Cardiovascular diseases

References

1. Bartesaghi S, Radi R. Fundamentals on the biochemistry of peroxynitrite and protein tyrosine nitration. Redox Biol. 2018;14:618‑625.
2. Petre BA. Proteomics of Nitrotyrosine: Integrating Mass Spectrometry and Immunodetection in Redox‑Driven Pathology. Mass Spectrom Rev. Published online January 28, 2026.