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Thyroid/Other Endodermal Organ Lineages Derived from Pluripotent Stem Cells

Thyroid Hypothyroidism, Congenital Thyroid Developmental Defects, Brain–Lung–Thyroid Syndrome, and Hormone Dependence after Thyroid Surgery represent major unmet clinical needs in endocrine medicine.

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Pluripotent Stem Cell-Derived Pancreatic Lineage

Type 1 diabetes is caused by autoimmune destruction of pancreatic β cells, leaving patients dependent on exogenous insulin for life and prone to severe complications such as diabetic nephropathy, blindness, and cardiovascular diseases.

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Pluripotent Stem Cell-derived Intestinal Lineage

The clinical demand for diseases such as inflammatory bowel disease, short bowel syndrome, congenital intestinal endocrine deficiencies, and genetic disorders affecting intestinal absorption and metabolism continues to increase.

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Pluripotent stem cell-derived lung/airway lineage

The incidence of various respiratory diseases, including chronic obstructive pulmonary disease, idiopathic pulmonary fibrosis, cystic fibrosis, and congenital pulmonary surfactant deficiency disorders, continues to rise, creating a significant unmet need for clinical treatment and new drug development.

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Pluripotent Stem Cell-Derived Gastric Lineage

The global population infected with Helicobacter pylori is enormous, and gastrointestinal diseases including gastritis, peptic ulcers, gastric antral dysplasia, and gastric cancer occur at high incidence, with lesions frequently concentrated in the gastric antrum.

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Neural Progenitor Cells Derived from Pluripotent Stem Cells

Pluripotent stem cells (ESCs/iPSCs) possess the potential to differentiate into diverse cell lineages and serve as important cellular sources for constructing neurological disease models, drug screening platforms, and regenerative medicine research.

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Epithelial Stem Cells Derived from Pluripotent Stem Cells

Epithelial tissues are essential barrier and functional tissues in the human body, widely distributed in the skin, cornea, hair follicles, and the surfaces of various organs.

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