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Pluripotent Stem Cell-Derived Vascular Endothelial Lineage

Vascular endothelial cells are the core functional cells that constitute systemic microcirculation, regulate angiogenesis, and maintain tissue perfusion.

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Thyroid/Other Endodermal Organ Lineages Derived from Pluripotent Stem Cells

Thyroid Hypothyroidism, Congenital Thyroid Developmental Defects, Brain–Lung–Thyroid Syndrome, and Hormone Dependence after Thyroid Surgery represent major unmet clinical needs in endocrine medicine.

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Pluripotent Stem Cell-Derived Gastric Lineage

The global population infected with Helicobacter pylori is enormous, and gastrointestinal diseases including gastritis, peptic ulcers, gastric antral dysplasia, and gastric cancer occur at high incidence, with lesions frequently concentrated in the gastric antrum.

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Pluripotent stem cell-derived lung/airway lineage

The incidence of various respiratory diseases, including chronic obstructive pulmonary disease, idiopathic pulmonary fibrosis, cystic fibrosis, and congenital pulmonary surfactant deficiency disorders, continues to rise, creating a significant unmet need for clinical treatment and new drug development.

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Pluripotent Stem Cell-derived Intestinal Lineage

The clinical demand for diseases such as inflammatory bowel disease, short bowel syndrome, congenital intestinal endocrine deficiencies, and genetic disorders affecting intestinal absorption and metabolism continues to increase.

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Pluripotent Stem Cell-Derived Pancreatic Lineage

Type 1 diabetes is caused by autoimmune destruction of pancreatic β cells, leaving patients dependent on exogenous insulin for life and prone to severe complications such as diabetic nephropathy, blindness, and cardiovascular diseases.

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Hematological CSCs

Hematological Cancer Stem Cells (HCSCs) are a distinct population of cells present in hematological malignancies that possess key stem cell-like properties, including self-renewal, long-term persistence, disease-initiating capacity, and therapy resistance.

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Solid Tumor CSCs

Solid Tumor Cancer Stem Cells (Solid Tumor CSCs) are a specialized subpopulation of cells present in various solid tumors that possess self-renewal capacity, differentiation potential, and tumor-initiating ability.

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Mesenchymal Stem Cell–Derived Adipocytes

Mesenchymal Stem Cells (MSCs) are adult stem cells with self-renewal capacity and multilineage differentiation potential, which can be directionally differentiated into adipocytes under specific induction conditions.

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