Recombinant Human TSLPR/CRLF2 Protein, C-hFc

Background:TSLPR (Thymic Stromal Lymphopoietin Receptor) is a type of cell surface receptor protein that plays a crucial role in the immune system. It is an important component of the TSLP (Thymic Stromal Lymphopoietin) signaling pathway, involved in regulating the maturation and activation of immune cells. TSLPR is primarily expressed on dendritic cells, T cells, and other immune cells; by binding to TSLP, it promotes the regulation of immune responses, particularly in allergic and inflammatory reactions. Furthermore, TSLPR has been confirmed to play an important role in the occurrence and development of certain diseases. Studies have shown that abnormal expression of TSLPR is related to immune disorders such as asthma and allergies, making it a potential therapeutic target. Its structural features include a classical extracellular ligand-binding domain and an intracellular signaling region, through which TSLPR can effectively mediate TSLP signal transduction and regulate immune system balance.