U-Blot® 14-3-3 ε Rabbit mAb

U-Blot® 14-3-3 ε Rabbit mAb
U-Blot® 14-3-3 ε Rabbit mAb
$268.00
Size:50μL
SKU: WR5105-50

Catalog No.: WR5105

Specification: 50μL/100μL

Stock: In stock

U-Blot® 14-3-3 ε Rabbit mAb Learn more

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Product information

Product detailsSpecificationsQ & AEducation

Background：This gene product belongs to the 14-3-3 family of proteins which mediate signal transduction by binding to phosphoserine-containing proteins. This highly conserved protein family is found in both plants and mammals, and this protein is 100% identical to the mouse ortholog. It interacts with CDC25 phosphatases, RAF1 and IRS1 proteins, suggesting its role in diverse biochemical activities related to signal transduction, such as cell division and regulation of insulin sensitivity. It has also been implicated in the pathogenesis of small cell lung cancer. Two transcript variants, one protein-coding and the other non-protein-coding, have been found for this gene. [provided by RefSeq, Aug 2008],

Product Overview

Catalog No.
WR5105
SKU
WR5105-50
Category
Rabbit mAbs
Product Type
Other
Size
50μL/100μL
Stock Status
In stock
Available Stock
20
Minimum Order Quantity
1

Storage & Compliance

Storage
-15°C to -25°C/1 year(Do not lower than -25°C)
Research Use Only
Yes

Additional Specifications

Target
14-3-3 ε
Reactivity
Human,Mouse,Rat
Application
WB,IF,ELISA
MW(Calculated)
29kD
MW(Observed)
29kD
Host Species
Rabbit
Isotype
IgG,Kappa
Conjugate/Modification
Unmodified
Modification site
--
Recommended Dilution Ratio
WB 1:2000-1:10000;IF 1:200-1:1000;ELISA 1:5000-1:20000;
Form
PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
Source
--
Purification
Protein A
Purity
--
storageCondition
-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration
--
Clonality
Monoclonal
Clone No.
PT1013R
Immunogen
--
Sequence
--
Specificity
Endogenous
Gene Name
YWHAE
Protein Name
14-3-3 protein epsilon
Other Name
YWHAE;14-3-3 protein epsilon;14-3-3E
Organism-1
Human
Gene ID-1
7531
SwissProt-1
P62258
Organism-2
Mouse
Gene ID-2
22627
SwissProt-2
P62259
Organism-3
Rat
Gene ID-3
29753
SwissProt-3
P62260
Organism-4
--
gene ID-4
--
SwissProt-4
--
Cellular Localization
Function:Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathway. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner.,similarity:Belongs to the 14-3-3 family.,subcellular location:Identified by mass spectrometry in melanosome fractions from stage I to stage IV.,subunit:Homodimer. Heterodimerizes with YWHAZ. Interacts with NDEL1, RGNEF and TIAM2 (By similarity). Interacts with HCV core protein. Interacts with ABL1 (phosphorylated form); the interaction retains it in the cytoplasm. Weakly interacts with CDKN1B.,

Tech Support

ucallm

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Documents

Datasheet, COA, SDS, and protocol files can be requested from technical support.

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Storage & Handling

Storage
-15°C to -25°C/1 year(Do not lower than -25°C)
06

Contact Support

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Keywords:Rabbit mAbs