U-Blot® Histone H3 (Di Methyl Lys18) Rabbit mAb

U-Blot® Histone H3 (Di Methyl Lys18) Rabbit mAb
U-Blot® Histone H3 (Di Methyl Lys18) Rabbit mAb
$700.00
Size:100μL
SKU: WT8421-100

Catalog No.: WT8421

Specification: 100μL/300μL

Stock: In stock

Product details, specifications, documents, and related products are available from the catalog record. Learn more

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Product information

Product detailsSpecificationsQ & AEducation

Background: Histone H3 forms H3-H4 tetramers as nucleosome core scaffold. Lysine dimethylation is a reversible epigenetic modification controlled by methyltransferases and demethylases. Different dimethyl marks recruit specific reader proteins to regulate poised transcription, heterochromatin formation, DNA repair and cell differentiation. Each lysine site on H3 carries unique biological functions. H3K18me2 mainly locates at super-enhancers of pluripotent cells. It restricts excessive transcription and safeguards cell identity during lineage differentiation. Abnormal reduction of H3K18me2 drives uncontrolled tumor cell proliferation.

Product Overview

Catalog No.
WT8421
SKU
WT8421-100
Category
Histone Modification Antibodies
Product Type
Other
Size
100μL/300μL
Stock Status
In stock
Available Stock
20
Minimum Order Quantity
1

Storage & Compliance

Storage
-20.0°C
Research Use Only
Yes

Additional Specifications

Target
Dimethylated Histone H3 Lysine 18, H3K18me2
Reactivity
Human Vertebrates
Application
WB, ELISA, Luminex
MW(Calculated)
15kD
MW(Observed)
--
Host Species
Rabbit
Isotype
Rabbit IgG
Conjugate
Unconjugated
Modification
Di Methyl
Modification site
Lys18
Recommended dilution ratio
WB 0.2 ug/mL – 1 ug/mL; ELISA 0.1 ug/mL - 0.5 ug/mL; Luminex 0.1 ug/mL – 0.5 ug/mL.
Formulation
50% Glycerol/PBS with 1% BSA and 0.09% sodium azide
Source
--
Purification
Protein A affinity purified from an animal origin-free culture supernatant
Purity
--
Storage
-20.0°C
Concentration
1 mg/mL
Clonality
Recombinant Monoclonal
Clone Number
WR-202
Immunogen
A dimethyl-peptide corresponding to Dimethyl-Histone H3 (Lys18).
Sequence
--
Specificity
This antibody reacts to Histone H3 dimethylated at Lysine 18 (K18me2). No cross reactivity with monomethylated Lysine 18 (K18me1) or trimethylated Lysine 18 (K18me3), or other methylation in histone H3.
Gene name
--
Protein name
--
Alternative name
H3K18me2
Organism-1
Human
Gene ID‑1
8350;8351;8352;8353;8354;8355;8356;8357;8358;8968
SwissProt-1
P68431;Q71DI3;P84243
Organism-2
Mouse
Gene ID‑2
319152;15077;15078
SwissProt-2
--
Organism-3
Rat
Gene ID‑3
291159;100361558
SwissProt-3
Q6LED0;P84245
Organism-4
--
Gene ID‑4
--
SwissProt-4
--
Cellular Localization
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Tech Support

ucallm

01

Documents

Datasheet, COA, SDS, and protocol files can be requested from technical support.

02

Storage & Handling

Storage
-20.0°C
03

Contact Support

Emailinfo@mail.ucallm.com

Phone+(1)-866-986-9598

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HoursMonday-Friday 09:00-18:00 CST

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Keywords:Histone Modification Antibodies