info@ucallmlabs.com
Introduction
Lysine 2‑hydroxyisobutyrylation (Khib) is a widespread lysine acylation modification conserved across prokaryotic and eukaryotic organisms. Khib is predominantly enriched on histone proteins located at transcriptionally active genomic regions, highlighting its involvement in chromatin regulation and gene expression. Increasing evidence indicates that Khib participates in gene expression regulation, cellular differentiation, and metabolic processes.
Products Solutions
We provide comprehensive solutions for the detection and enrichment of Khib, featuring a multi‑epitope monoclonal antibody mix for enhanced modification coverage and detection performance.
- Multi‑epitope monoclonal antibody mix
- Diverse antibody formats
- Khib‑specific enrichment reagent
Product List
| Product Type | Product Name | Catalog No. |
|---|---|---|
| Rabbit pAb | Pan‑2‑Hydroxyisobutyryllysine Rabbit pAb | WT9007 |
| Rabbit mAb | Pan‑2‑Hydroxyisobutyryllysine Rabbit mAb | WT9008 |
| Mouse mAb | Pan‑2‑Hydroxyisobutyryllysine Mouse mAb | WT9171 |
| MultiPTM | 2‑Hydroxyisobutyryllysine MultiPTM Rabbit Monoclonal Antibody mix | WT9008M |
Research Areas
- Epigenetic regulation and gene expression
- Central carbon metabolism
- Reproductive biology
- Plant and microbial biology
References
- Dai L, Peng C, Montellier E, et al. Lysine 2‑hydroxyisobutyrylation is a widely distributed active histone mark. Nat Chem Biol. 2014;10(5):365‑370.
- Huang H, Luo Z, Qi S, et al. Landscape of the regulatory elements for lysine 2‑hydroxyisobutyrylation pathway. Cell Res. 2018;28(1):111‑125.
- Li Q, Fu C, Hu B, et al. Lysine 2‑hydroxyisobutyrylation proteomics analyses reveal the regulatory mechanism of CaMYB61‑CaAFR1 module in regulating stem development in Capsicum annuum L. Plant J. 2024;119(2):1039‑1058.
- Huang H, Tang S, Ji M, et al. p300‑Mediated Lysine 2‑Hydroxyisobutyrylation Regulates Glycolysis. Mol Cell. 2018;70(4):663‑678.e6.