CUT&Tag Technology: High-Resolution Chromatin Profiling with Low Input and Streamlined Workflow

The exploration of chromatin states and gene regulatory mechanisms has advanced rapidly, moving from traditional ChIP-seq to more sensitive and streamlined approaches. Among these, Cleavage Under Targets and Tagmentation (CUT&Tag) has emerged as a powerful tool, distinguished by its unique enzyme-tethering design. By combining antibody-directed targeting with in situ transposase activity, CUT&Tag enables robust, high-resolution epigenomic profiling from very small samples, including single cells.