Fumarylation

Introduction

Lysine fumarylation (Kfu) is a recently identified PTM first characterized in Escherichia coli. The fumaryl group is installed onto lysine residues by SpeG and removed by CobB. Derived from fumarate, a key metabolite of the TCA cycle, Kfu participates in cellular stress adaptation, including temperature and oxidative stress responses.

Products Solutions

Our Kfu products include pan‑fumaryllysine antibodies, a MultiPTM Rabbit Monoclonal Antibody Mix, and fumaryllysine‑specific agarose beads, providing flexible tools for Kfu modification detection and enrichment.

• Multiple monoclonal antibodies mix for enhanced Kfu recognition
• Kfu‑specific detection
• Targeted Kfu enrichment

Product List

Product Type	Product Name	Catalog No.
Rabbit pAb	Pan‑Fumaryllysine Rabbit pAb	WT9034
Rabbit mAb	Pan‑Fumaryllysine Rabbit mAb	WT9035
MultiPTM	Fumaryllysine MultiPTM Rabbit Monoclonal Antibody mix	WT9035M
Agarose Conjugated	Fumaryllysine Specific Antibody Conjugated Agarose Beads	WT9157B

Research Areas

• Stress responses

References

1. Chen C, Zhang X, Bai X, et al. Discovery and Enzymatic Regulation of Lysine Fumarylation, a Post‑Translational Modification in Bacteria. J Am Chem Soc. 2026;148(15):16502‑16514.