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Introduction
Lysine glutarylation (Kglu) is a reversible lysine acylation modification derived from glutaryl‑CoA. By introducing glutaryl groups onto lysine residues, Kglu alters protein physicochemical properties and influences protein interactions and functions. Kglu is enriched in mitochondrial proteins and has been implicated in mitochondrial function and metabolic regulation.
Products Solutions
Our products are designed for the detection and enrichment of Kglu, featuring a mixture of monoclonal antibodies targeting different Kglu epitopes to broaden detection of Kglu‑modified proteins.
- Multi‑antibody recognition for broader Kglu detection
- Flexible antibody formats for Kglu detection
- Specific enrichment of Kglu‑modified proteins and peptides
Product List
| Product Type | Product Name | Catalog No. |
|---|---|---|
| Rabbit pAb | Pan‑Glutaryllysine Rabbit pAb | WT9022 |
| Rabbit mAb | Pan‑Glutaryllysine Rabbit mAb | WT9023 |
| Mouse mAb | Pan‑Glutaryllysine Mouse mAb | WT9174 |
| MultiPTM | Glutaryllysine MultiPTM Rabbit Monoclonal Antibody mix | WT9023M |
| Motif (Glut‑K) Kit | Glutaryl‑Lysine Motif (Glut‑K) Kit | WT916K |
| Agarose Conjugated | Glutaryl Lysine Specific Antibody Conjugated Agarose Beads | WT9163B |
Research Areas
- Mitochondrial function
- Reproductive biology
- Metabolic disorders
References
- Tan M, Peng C, Anderson KA, et al. Lysine glutarylation is a protein posttranslational modification regulated by SIRT5. Cell Metab. 2014;19(4):605‑617.
- Schmiesing J, Storch S, Dörfler AC, et al. Disease‑Linked Glutarylation Impairs Function and Interactions of Mitochondrial Proteins and Contributes to Mitochondrial Heterogeneity. Cell Rep. 2018;24(11):2946‑2956.
- Grice GL, Minogue E, Coates HW, et al. Lipoyl deglutarylation by ABHD11 regulates mitochondrial and T cell metabolism. Nat Chem Biol. 2025;21(12):1915‑1926.