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Immortalized immune cell lines are typically derived from human or animal hematopoietic cells, tumor cells, or other immune-related cell types and acquire stable proliferative capacity after long-term culture.
These cell lines offer advantages including easy maintenance, high expansion capacity, low batch-to-batch variability, and suitability for standardized experiments. Therefore, they are widely used in studies of immune signaling pathways, cell proliferation, cell death, drug screening, gene expression, and transfection experiments.
Commonly Used Immune Cell Lines
| Cell Line | Origin | Cell Type | Common Research Applications |
| Jurkat | Human T-cell leukemia | T lymphocyte / T-cell line | TCR signaling, T-cell activation, NFAT/NF-κB pathways, IL-2 regulation, and T-cell signaling studies |
| THP-1 | Human acute monocytic leukemia | Monocyte-like cell | Monocyte differentiation, macrophage polarization, inflammation, and TLR/NF-κB signaling studies |
| U937 | Human histiocytic lymphoma | Monocyte-like cell | Monocyte/macrophage differentiation, inflammation, phagocytosis, and drug studies |
| Raji | Human Burkitt lymphoma | B lymphocyte | BCR signaling, B-cell biology, antibody-related studies, and immune regulation research |
| Daudi | Human Burkitt lymphoma | B lymphocyte | B-cell studies, interferon responses, and NK cell-mediated cytotoxicity assays |
| K562 | Human chronic myeloid leukemia | Myeloid / leukemia cell | NK cell cytotoxicity assays, cell killing mechanisms, leukemia research, and drug screening |
| NK-92 | Human NK cell line | NK cell | NK-cell activation, cytotoxicity, tumor cell killing, and NK cell-based immunotherapy research |
| RAW 264.7 | Mouse tumor-derived cell line | Macrophage-like cell | Macrophage activation, LPS/TLR4 signaling, NF-κB pathway, inflammation, phagocytosis, and polarization studies |
Learn more about our cell culture products