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Leucylation
Introduction
Lysine leucylation (KLeu) represents a unique connection between amino acid metabolism and protein modification. By using leucyl‑tRNA as the donor, KLeu introduces leucine residues onto lysine sites, creating an amino acid‑based regulatory mechanism distinct from conventional acylations. KLeu has been implicated in the regulation of protein function and cellular adaptation to nutrient conditions.
Products Solutions
Our KLeu products include pan‑leucyllysine antibodies and a MultiPTM Rabbit Monoclonal Antibody Mix, offering flexible detection options and enhanced recognition of KLeu‑modified proteins.
- Multi‑epitope KLeu recognition
- Specific detection of KLeu modification
Product List
| Product Type | Product Name | Catalog No. |
|---|---|---|
| Rabbit pAb | Pan‑Leucyllysine Rabbit pAb | WT9026 |
| Rabbit mAb | Pan‑Leucyllysine Rabbit mAb | WT9027 |
| MultiPTM | Leucyllysine MultiPTM Rabbit Monoclonal Antibody mix | WT9027M |
Research Areas
- Amino acid metabolic sensing
- Nutrient response and metabolic adaptation
References
- He XD, Gong W, Zhang JN, et al. Sensing and Transmitting Intracellular Amino Acid Signals through Reversible Lysine Aminoacylations. Cell Metab. 2018;27(1):151‑166.e6.
- Zhang X, Liu L, Chen WC, et al. Gestational Leucylation Suppresses Embryonic T‑Box Transcription Factor 5 Signal and Causes Congenital Heart Disease. Adv Sci (Weinh). 2022;9(15):e2201034.