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Methacrylation
Introduction
Lysine methacrylation (Kmea) is a new type of posttranslational modification and a structural isomer of crotonyllysine (Kcr). Kmea is a reversible PTM, which is related by HAT1 as a methacryltransferase and SIRT2 as a demethacrylase. The discovery of Kmea provides new insights into the interplay between metabolism and epigenetic regulation.
Products Solutions
Our Kmea products include pan‑methacryllysine antibodies and a MultiPTM Rabbit Monoclonal Antibody Mix, providing reliable tools for lysine methacrylation detection.
- Multi‑epitope Kmea recognition
- Specific Kmea Detection
Product List
| Product Type | Product Name | Catalog No. |
|---|---|---|
| Rabbit pAb | PanMethacrylllysine Rabbit pAb | WT9032 |
| Rabbit mAb | PanMethacrylllysine Rabbit mAb | WT9033 |
| Mouse mAb | PanMethacrylllysine Mouse mAb | WT9177R |
| MultiPTM | Methacrylllysine MultiPTM Rabbit Monoclonal Antibody mix | WT9033M |
Research Areas
- Metabolism
References
- Delaney K, Tan M, Zhu Z, et al. Histone lysine methacrylation is a dynamic post‑translational modification regulated by HAT1 and SIRT2. Cell Discov. 2021;7(1):122.
- Zhu TY, Chen SY, Zhang M, et al. Genetically encoding ε‑N‑methacryllysine into proteins in live cells. Nat Commun. 2025;16(1):2623.