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Introduction
Protein citrullination is an irreversible PTM that converts arginine residues to citrulline through peptidyl arginine deiminases (PADs). By altering protein charge and molecular interactions, citrullination plays important roles in immune regulation and disease.
Products Solutions
Our human protein citrullination arrays provide a high‑throughput platform for profiling protein citrullination across hundreds to thousands of predefined targets. Multiple array formats enable multiplex analysis at different screening scales.
- High‑throughput citrullination profiling
- Multiplex protein analysis
- Broad target coverage
- Multiple array formats
Research Areas
- Autoimmune Diseases
- Immunology & Inflammation
- Cancer Research
References
- Curran AM, Girgis AA, Jang Y, et al. Citrullination modulates antigen processing and presentation by revealing cryptic epitopes in rheumatoid arthritis. Nat Commun. 2023;14(1):1061.
- Zhu YP, Speir M, Tan Z, et al. NET formation is a default epigenetic program controlled by PAD4 in apoptotic neutrophils. Sci Adv. 2023;9(51):eadj1397.
- Indeglia A, Valdespino A, Pantella G, et al. Targeted citrullination enables p53 binding to non‑canonical sites. Mol Cell. 2025;85(19):3588‑3604.e11.
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