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Pyruvylation
Introduction
Lysine pyruvylation (Kpy) is a metabolite‑associated modification derived from pyruvate, a central intermediate of glycolysis. The transfer of pyruvoyl groups to lysine residues is mediated by acyltransferases such as p300 and HAT1, while SIRT3 contributes to the removal of this modification. Kpy has been implicated in the regulation of protein function and cellular processes associated with metabolic adaptation.
Products Solutions
Pan‑Pyruvyllysine Rabbit pAb enables reliable detection of lysine pyruvylation, supporting investigation of Kpy modification patterns and biological functions.
- Specific Kpy Recognition
- Reliable detection of pyruvylation modification
Product List
| Product Type | Product Name | Catalog No. |
|---|---|---|
| Rabbit pAb | Pan‑Pyruvyllysine Rabbit pAb | WT9126 |
Research Areas
- Antiviral immunity
- Epigenetic regulation
References
- Zuo Y, Wang Q, Tian W, et al. Pyruvate is a natural suppressor of interferon signaling by inducing STAT1 protein pyruvylation. Cell. 2026;189(7):1975‑1989.e19.
- Song X, Peng P, Zheng H, et al. Lysine pyruvylation couples glycolytic flux to epigenetic regulation. Nat Metab. Published online July 3, 2026.
- Guo W, Xiao W. Pyruvylation: a new post‑translational modification mechanism. Trends Endocrinol Metab. 2026;37(7):601‑603.