info@ucallmlabs.com
Introduction
Serotonylation is a recently characterized PTM, wherein serotonin is covalently conjugated to glutamine residues of substrate proteins. This reaction is catalyzed by transglutaminases, and target substrates include small GTPases, fibronectin, cytoskeletal proteins, and histones. Serotonylation remodels the molecular functions of these proteins, thereby modulating diverse cellular signaling pathways and biological regulatory processes.
Products Solutions
We provide serotonylation antibodies for specific detection of Serotonyl‑Gln modification. Our featured MultiPTM antibody mix improves the detection efficiency of serotonylation.
- Specific serotonyl‑Gln recognition
- Enhanced serotonylation detection with MultiPTM Antibody Mix
- Reliable tools for serotonylation analysis
Product List
| Product Type | Product Name | Catalog No. |
|---|---|---|
| Rabbit pAb | PanSerotonylGlutamine Rabbit pAb | WT9038 |
| Rabbit mAb | PanSerotonylGlutamine Rabbit mAb | WT9039 |
| MultiPTM | SerotonylGlutamine MultiPTM Rabbit Monoclonal Antibody mix | WT9039M |
Research Areas
- Neuroscience and neurobiology
- Cancer biology
References
- Farrelly LA, Thompson RE, Zhao S, et al. Histone serotonylation is a permissive modification that enhances TFIID binding to H3K4me3. Nature. 2019;567(7749):535‑539.
- Chen HC, He P, McDonald M, et al. Histone serotonylation regulates ependymoma tumorigenesis. Nature. 2024;632(8026):903‑910.
- Dong R, Wang T, Dong W, et al. TGM2‑mediated histone serotonylation promotes HCC progression via MYC signalling pathway. J Hepatol. 2025;83(1):105‑118.
- Lin S, Tan S, Peng Y, et al. Histone serotonylation promotes pancreatic cancer development via lipid metabolism remodeling. Nat Commun. 2025;16(1):5947.