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From Cell–ECM Interaction to Mechanotransduction — Empowering Comprehensive Integrin Profiling with Validated Antibody Solutions
Integrins are a family of heterodimeric transmembrane receptors that serve as the primary interface between cells and the extracellular matrix (ECM). Through dynamic interactions with ECM components including collagen, laminin, and fibronectin, integrins regulate essential cellular processes such as adhesion, migration, proliferation, differentiation, survival, and mechanical sensing.Integrins consist of non-covalently associated α and β subunits that undergo conformational activation through inside-out and outside-in signaling mechanisms. Activated integrins recruit focal adhesion complexes and regulate downstream pathways controlling cytoskeletal remodeling, mechanotransduction, and cell fate decisions.
We support cutting-edge integrin research by enabling comprehensive analysis of cell–matrix interactions, receptor signaling, and tissue-level regulation across diverse biological fields. Validated integrin antibodies facilitate studies of tumor invasion, cancer stem cell maintenance, ECM remodeling, and metastatic niche formation. Beyond oncology, integrin profiling provides critical insights into fibrosis, immune cell trafficking, inflammation, stem cell niche regulation, and regenerative processes. Combined with spatial and single-cell technologies, integrin research reveals cellular heterogeneity, ECM communication networks, and complex tissue microenvironments, accelerating discoveries in cancer biology, immunology, regenerative medicine, and precision therapeutics.
Integrin Research Antibody Portfolio
——Comprehensive Antibody Solutions for Integrin Identification, Signaling and Functional Characterization
Reliable integrin research requires accurate detection of receptor expression, localization, and functional activation. Our validated integrin antibody portfolio covers major α and β subunits, supporting studies in ECM interaction, cell adhesion, migration, immune regulation, stem cell biology, and cancer progression.
Research Focus | Representative Markers | Key Applications | Biological Significance |
Core ECM Adhesion Receptors | ITGB1 (CD29), ITGA1, ITGA2, ITGA5, ITGA6 | Cell adhesion, migration, ECM interaction analysis | Major mediators of collagen, laminin and fibronectin binding |
Basement Membrane & Laminin Receptors | ITGA3 (CD49c), ITGA6 (CD49f), ITGB4 (CD104), ITGA7 | Epithelial biology, stem cell regulation, cancer invasion | Maintain basement membrane attachment and tissue organization |
Fibronectin & RGD-Binding Integrins | ITGA5, ITGAV (CD51), ITGB3 (CD61), ITGB5 | Angiogenesis, tumor progression, wound repair | Recognize RGD-containing ECM proteins and regulate migration |
Collagen Receptors | ITGA1, ITGA2, ITGA10, ITGA11 | Fibrosis, connective tissue biology, tissue remodeling | Mediate collagen-dependent adhesion and matrix organization |
Immune Cell Integrins | ITGB2 (CD18), ITGAM (CD11b), ITGAX (CD11c), ITGAE (CD103) | Immune trafficking, inflammation, tumor immunity | Control leukocyte adhesion, migration and immune surveillance |
Cancer-Associated Integrins | ITGA3, ITGA5, ITGA6, ITGAV, ITGB3 | EMT, invasion, metastasis, cancer stem cells | Promote tumor cell plasticity and metastatic dissemination |
Integrin Research Antibody Portfolio
—Comprehensive Antibody Solutions for Integrin Identification, Signaling, and Functional Characterization
Integrins are key extracellular matrix (ECM) receptors that regulate cell adhesion, migration, mechanotransduction, immune trafficking, stem cell maintenance, and tumor progression. We provide validated integrin antibodies enabling precise investigation of integrin expression, localization, signaling activation, and functional roles across cancer biology, immunology, regenerative medicine, and tissue remodeling research.
Marker | Biological Function | Research Value | Associated Research Applications |
Integrin β1 (CD29) | Central ECM adhesion receptor forming heterodimers with multiple α subunits to regulate cell adhesion, migration, and survival signaling | Fundamental marker for studying ECM interactions, mechanotransduction, and integrin-mediated signaling pathways | Cell adhesion studies, tumor progression, stem cell biology, tissue remodeling |
Integrin α1 (CD49a) | Collagen and laminin receptor involved in extracellular matrix attachment and cellular signaling | Enables analysis of collagen-dependent adhesion and tissue organization mechanisms | Fibrosis research, connective tissue biology, immune regulation |
Integrin α2 (CD49b) | Collagen-binding integrin regulating cell–matrix interactions and migration | Important for investigating collagen remodeling and invasive behavior | Cancer invasion, wound healing, ECM remodeling |
Integrin α5 (CD49e) | Fibronectin receptor forming α5β1 integrin complex to regulate adhesion and migration | Key biomarker for fibronectin-mediated signaling and tumor cell motility | Angiogenesis, cancer metastasis, migration studies |
Integrin α6 (CD49f) | Laminin receptor involved in basement membrane attachment and epithelial organization | Widely used marker for stem/progenitor populations and tumor-initiating cells | Cancer stem cell research, epithelial biology, regenerative medicine |
Integrin β4 (CD104) | Hemidesmosome-associated receptor maintaining epithelial adhesion and tissue integrity | Provides insights into epithelial stability, invasion, and tumor plasticity | Cancer invasion, epithelial remodeling, metastasis research |
Integrin αV (CD51) | RGD-binding integrin subunit regulating ECM recognition, angiogenesis, and cell migration | Important target for studying tumor angiogenesis and metastatic signaling | Tumor microenvironment, vascular biology, wound repair |
Integrin β3 (CD61) | RGD-binding integrin partner involved in platelet function, angiogenesis, and tumor cell migration | Valuable marker for investigating integrin activation and metastatic progression | Angiogenesis, cancer progression, platelet–tumor interactions |
Integrin β5 | ECM receptor involved in vitronectin binding, cell survival, and migration signaling | Supports investigation of adhesion-dependent survival pathways | Tumor progression, angiogenesis, cell migration |
Integrin β2 (CD18) | Leukocyte-specific integrin subunit mediating immune cell adhesion and trafficking | Essential marker for immune-cell recruitment and inflammatory responses | Immunology, inflammation, immune infiltration studies |
Integrin αM (CD11b) | Myeloid-associated integrin regulating macrophage adhesion, migration, and phagocytosis | Enables characterization of myeloid cell activation and immune microenvironment remodeling | Tumor-associated macrophages, inflammation, immuno-oncology |
Integrin αX (CD11c) | Dendritic cell-associated integrin involved in antigen presentation and immune surveillance | Useful for identifying antigen-presenting immune populations | Dendritic cell biology, immune profiling, tumor immunity |
Integrin αE (CD103) | Tissue-resident immune cell integrin mediating epithelial retention and immune surveillance | Marker for tissue-resident cytotoxic immune populations and anti-tumor immunity | Tumor immune microenvironment, T-cell infiltration studies |
Integrin α10 | Collagen-binding receptor associated with cartilage and connective tissue organization | Provides insights into collagen-rich tissue biology and matrix regulation | Cartilage biology, fibrosis, tissue engineering |
Integrin α11 | Fibroblast-associated collagen receptor regulating matrix organization and remodeling | Emerging marker for stromal activation and tumor-associated fibroblast biology | Fibrosis research, tumor stroma analysis |
Integrin α3 (CD49c) | Laminin and ECM receptor involved in epithelial adhesion and invasion | Supports studies of epithelial integrity and metastatic potential | Cancer invasion, epithelial-mesenchymal transition (EMT) |
Integrin α7 | Laminin receptor involved in muscle development and cell–matrix interactions | Useful for studying tissue-specific adhesion mechanisms | Muscle biology, regenerative medicine |
Integrin αVβ3 | Activated RGD-binding integrin promoting angiogenesis, migration, and survival signaling | Major therapeutic and imaging target for tumor vascularization studies | Cancer angiogenesis, metastasis, drug development |
Integrin α6β4 | Laminin receptor associated with hemidesmosome formation and invasive signaling | Links epithelial adhesion with tumor progression and invasion | Carcinoma progression, EMT, metastasis |
Integrin α5β1 | Fibronectin receptor regulating migration, proliferation, and ECM remodeling | Key model system for studying adhesion-dependent signaling | Cancer migration, fibrosis, tissue repair |
Featured Integrin Research Solutions
——Comprehensive Marker Panels for Functional Integrin Biology
ECM Adhesion and Cell–Matrix Interaction——Defining Integrin-Mediated Cellular Attachment
Key Markers
ITGA1 (CD49a) | ITGA2 (CD49b) | ITGA5 (CD49e) | ITGB1 (CD29) | ITGB4 (CD104) |
Cancer Progression and Metastasis—Tracking Integrin-Driven Tumor Invasion
Key Markers
ITGA3 (CD49c) | ITGA5 (CD49e) | ITGA6 (CD49f) | ITGAV (CD51) | ITGB3 (CD61) |
Immune Cell Adhesion and Inflammation—Characterizing Leukocyte Integrin Function
Key Markers
ITGB2 (CD18) | ITGAM (CD11b) | ITGAX (CD11c) | ITGAE (CD103) |
Mechanotransduction Research Panel—Characterizing Integrin-Mediated Focal Adhesion and YAP/TAZ Mechanosignaling
Key Markers:
ITGB1 | ITGA5 | FAK/ p-FAK | Vinculin | YAP | TAZ |
Stem Cell Niche & Regeneration Panel—Profiling Integrin-Laminin Receptor Dynamics in Stemness and Repair
ITGA6 | ITGB1 | ITGA7 | Laminin receptors | YAP | TAZ |
Integrin & ECM Receptor Research
——From Receptor Profiling to Functional Signaling and Translational Discovery
Research Stage | Representative Markers | Scientific Objective |
1. Integrin Expression & Subtype Profiling | ITGA1, ITGA3, ITGA5, ITGA6, ITGB1, ITGB4 | Define integrin expression patterns, receptor distribution, and cell-type-specific adhesion profiles across tissues and biological systems |
2. ECM Recognition & Adhesion Mechanism Analysis | ITGB1, ITGB4, ITGAV, ITGA5 | Investigate integrin-mediated interactions with major ECM components including collagen, laminin, fibronectin, and vitronectin |
3. Integrin Signaling Pathway Investigation | ITGB1, ITGB3, FAK, Paxillin, Src, Talin | Characterize downstream signaling networks controlling adhesion, mechanotransduction, proliferation, and survival |
4. Cell Migration, Invasion & Metastasis Studies | ITGA5, ITGA6, ITGB3, ITGAV | Analyze integrin-driven cellular motility, epithelial–mesenchymal transition (EMT), tumor invasion, and metastatic dissemination |
5. Immune Cell Adhesion & Inflammatory Regulation | ITGB2 (CD18), ITGAM (CD11b), ITGAX (CD11c), ITGAE (CD103) | Define immune-cell trafficking, leukocyte adhesion, tissue infiltration, and tumor immune microenvironment remodeling |
6. Stem Cell Niche & Regenerative Biology | ITGA6 (CD49f), ITGB1 (CD29), ITGA7 | Investigate integrin-mediated regulation of stem cell maintenance, differentiation, tissue repair, and regenerative processes |
7. Functional Validation & Therapeutic Target Discovery | Integrin receptors + downstream signaling markers | Connect integrin expression and activation states with biological functions, therapeutic responses, and disease mechanisms |
We provide comprehensive integrin research solutions enabling systematic investigation of receptor expression, ECM interactions, intracellular signaling, and functional outcomes. Validated integrin markers support profiling of adhesion receptor patterns, analysis of collagen/laminin/fibronectin interactions, and characterization of pathways regulating migration, invasion, immune trafficking, and stem cell behavior. By integrating integrin expression analysis with downstream signaling validation, researchers can uncover mechanisms underlying tumor progression, inflammation, tissue remodeling, and regeneration. These advanced antibody-based approaches accelerate functional discovery and therapeutic target identification across cancer biology, immunology, and regenerative medicine.
Why Researchers Choose Our Integrin Antibody Solutions?
Validated Markers. Comprehensive Coverage. Confident Integrin Research.
Our recombinant antibody portfolio supports complete integrin research workflows, from receptor expression profiling and ECM interaction analysis to disease mechanism investigation.
Research Challenge | Our Solution |
How can I identify integrin expression patterns? | Comprehensive α/β integrin marker coverage for tissue and cellular profiling |
How can I study ECM adhesion mechanisms? | Validated antibodies targeting collagen, laminin, and fibronectin receptors |
How can I investigate tumor invasion pathways? | Cancer-associated integrin markers including ITGA3, ITGA5, ITGA6, ITGAV and ITGB3 |
How can I analyze immune cell migration? | Immune integrin markers including ITGB2, CD11b and CD11c |
How can I improve experimental reproducibility? | Recombinant monoclonal antibodies with high specificity and lot-to-lot consistency |
Key References
Chastney M.R., Kaivola J., Leppänen V.M., Ivaska J. (2025).The role and regulation of integrins in cell migration and invasion.Nature Reviews Molecular Cell Biology. 26:147–167.
Haake S.M., Rios B.L., Pozzi A., Zent R. (2024).Integrating integrins with the hallmarks of cancer.Matrix Biology. 130:20–35.
Arnaout M.A. (2025).The integrin receptors: from discovery to structure to medicines.Immunological Reviews. 329(1):e13433.
Miao M.Z., Lee J.S., Yamada K.M., Loeser R.F. (2024).Integrin signalling in joint development, homeostasis and osteoarthritis.Nature Reviews Rheumatology. 20:492–509.
Massey A., Stewart J., Smith C., et al. (2024).Mechanical properties of human tumour tissues and their implications for cancer development. Nature Reviews Physics. 6:269–282.
Sleeboom J.J.F., van Tienderen G.S., Schenke-Layland K., et al. (2024).The extracellular matrix as hallmark of cancer and metastasis: From biomechanics to therapeutic targets.Science Translational Medicine. 16(728):eadg3840.
Sun Z., Costell M., Fässler R. (2019). Integrin activation by talin, kindlin and mechanical forces. Nature Cell Biology. 21:25–31.
Horton E.R., Byron A., Askari J.A., et al. (2016). Definition of a consensus integrin adhesome and its dynamics during cell migration. Nature Cell Biology. 18:999–1011.
Cooper J., Giancotti F.G. (2019). Integrin signaling in cancer: mechanotransduction, stemness, epithelial plasticity. Nature Reviews Cancer. 19:537–554.