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Neural Stem Cell-derived Neurons 

Neural Stem Cells (NSCs) are neural progenitor cells with self-renewal capacity and multipotent differentiation potential.

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Thyroid/Other Endodermal Organ Lineages Derived from Pluripotent Stem Cells

Thyroid Hypothyroidism, Congenital Thyroid Developmental Defects, Brain–Lung–Thyroid Syndrome, and Hormone Dependence after Thyroid Surgery represent major unmet clinical needs in endocrine medicine.

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Pluripotent Stem Cell-Derived Hepatic Lineage

The clinical demand for end-stage liver failure, hereditary metabolic liver diseases, viral hepatitis, and drug-induced liver injury continues to increase, while donor liver resources remain extremely limited, restricting the application of liver transplantation and hepatocyte transplantation.

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Pluripotent Stem Cell-Derived Pancreatic Lineage

Type 1 diabetes is caused by autoimmune destruction of pancreatic β cells, leaving patients dependent on exogenous insulin for life and prone to severe complications such as diabetic nephropathy, blindness, and cardiovascular diseases.

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Pluripotent Stem Cell-derived Intestinal Lineage

The clinical demand for diseases such as inflammatory bowel disease, short bowel syndrome, congenital intestinal endocrine deficiencies, and genetic disorders affecting intestinal absorption and metabolism continues to increase.

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Pluripotent stem cell-derived lung/airway lineage

The incidence of various respiratory diseases, including chronic obstructive pulmonary disease, idiopathic pulmonary fibrosis, cystic fibrosis, and congenital pulmonary surfactant deficiency disorders, continues to rise, creating a significant unmet need for clinical treatment and new drug development.

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Pluripotent Stem Cell-Derived Gastric Lineage

The global population infected with Helicobacter pylori is enormous, and gastrointestinal diseases including gastritis, peptic ulcers, gastric antral dysplasia, and gastric cancer occur at high incidence, with lesions frequently concentrated in the gastric antrum.

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Pluripotent Stem Cell-Derived Reproductive System Lineage

Reproductive disorders, infertility, and diseases associated with germ cell development represent major unmet clinical needs.

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Pluripotent Stem Cell-Derived Renal Mesoderm Lineage

Chronic kidney disease and end-stage renal failure affect a large global patient population, while the shortage of kidney organ donors remains a major challenge.

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