U-Blot® OPTN rabbit pAb

U-Blot® OPTN rabbit pAb
U-Blot® OPTN rabbit pAb
$0.00
SKU: WP26776

Specification: 50µL/100µL

Stock: In stock

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Product information

Product detailsSpecificationsQ & AEducation

Background：This gene encodes the coiled-coil containing protein optineurin. Optineurin may play a role in normal-tension glaucoma and adult-onset primary open angle glaucoma. Optineurin interacts with adenovirus E3-14.7K protein and may utilize tumor necrosis factor-alpha or Fas-ligand pathways to mediate apoptosis, inflammation or vasoconstriction. Optineurin may also function in cellular morphogenesis and membrane trafficking, vesicle trafficking, and transcription activation through its interactions with the RAB8, huntingtin, and transcription factor IIIA proteins. Alternative splicing results in multiple transcript variants encoding the same protein. [provided by RefSeq, Jul 2008]

Product Overview

Catalog No.
WP26776
SKU
WP26776
Category
Polyclonal antibodies
Product Type
Other
Size
50µL/100µL
Stock Status
In stock
Available Stock
999
Minimum Order Quantity
1

Storage & Compliance

Research Use Only
Yes

Additional Specifications

Target
OPTN
Reactivity
Human, Mouse, Rat
Applications
WB
MW(Calculated)
--
MW(Observed)
65kD,42kD
Host Species
Rabbit
Isotype
IgG
Conjugate/Modification
Unmodified
Recommended Dilution Ratio
WB 1:500-2000
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage
-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration
1 mg/ml
Clonality
Polyclonal
Immunogen
Synthesized peptide derived from human OPTN
Specificity
This antibody detects endogenous levels of OPTN at Human, Mouse,Rat
Gene Name
OPTN FIP2 GLC1E HIP7 HYPL NRP
Protein Name
OPTN
Other Name
Optineurin; / E3-14.7K-interacting protein; / FIP-2; / Huntingtin yeast partner L; / Huntingtin-interacting protein 7; / HIP-7; / Huntingtin-interacting protein L; / NEMO-related protein; / Optic neuropathy-inducing protein; / Transcription factor IIIA-interacting protein; / TFIIIA-IntP
Species
Human
Gene ID
10133
Uniprot
Q96CV9,
Species
Mouse
Gene ID
71648
Uniprot
Q8K3K8,
Species
Rat
Gene ID
246294
Uniprot
Q8R5M4
Cellular Localization
Cytoplasm, perinuclear region. Golgi apparatus . Golgi apparatus, trans-Golgi network. Cytoplasmic vesicle, autophagosome. Cytoplasmic vesicle. Recycling endosome. Found in the perinuclear region and associates with the Golgi apparatus (PubMed:27534431). Colocalizes with MYO6 and RAB8 at the Golgi complex and in vesicular structures close to the plasma membrane. Localizes to LC3-positive cytoplasmic vesicles upon induction of autophagy. .
Tissue Expression
Present in aqueous humor of the eye (at protein level). Highly expressed in trabecular meshwork. Expressed nonpigmented ciliary epithelium, retina, brain, adrenal cortex, fetus, lymphocyte, fibroblast, skeletal muscle, heart, liver, brain and placenta.
Signaling_pathway
Cellular Processes >> Transport and catabolism >> Autophagy - animal;Cellular Processes >> Transport and catabolism >> Mitophagy - animal;Human Diseases >> Neurodegenerative disease >> Amyotrophic lateral sclerosis;Human Diseases >> Neurodegenerative disease >> Pathways of neurodegeneration - multiple diseases
Research Areas
>>Mitophagy - animal; / >>Amyotrophic lateral sclerosis; / >>Pathways of neurodegeneration - multiple diseases
Function
--

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Keywords:Polyclonal antibodies