U-Blot® HO-1 Rabbit pAb

U-Blot® HO-1 Rabbit pAb
U-Blot® HO-1 Rabbit pAb
$0.00
SKU: WP26786

Specification: 50µL/100µL

Stock: In stock

Product details, specifications, documents, and related products are available from the catalog record. Learn more

1
Share:fx@link

Product information

Product detailsSpecificationsQ & AEducation

Background：heme oxygenase 1(HMOX1) Homo sapiens Heme oxygenase, an essential enzyme in heme catabolism, cleaves heme to form biliverdin, which is subsequently converted to bilirubin by biliverdin reductase, and carbon monoxide, a putative neurotransmitter. Heme oxygenase activity is induced by its substrate heme and by various nonheme substances. Heme oxygenase occurs as 2 isozymes, an inducible heme oxygenase-1 and a constitutive heme oxygenase-2. HMOX1 and HMOX2 belong to the heme oxygenase family. [provided by RefSeq, Jul 2008],

Product Overview

Catalog No.
WP26786
SKU
WP26786
Category
Polyclonal antibodies
Product Type
Other
Size
50µL/100µL
Stock Status
In stock
Available Stock
999
Minimum Order Quantity
1

Storage & Compliance

Research Use Only
Yes

Additional Specifications

Target
HO1
Reactivity
Human, Mouse
Applications
WB
MW(Calculated)
33kD
MW(Observed)
33kD
Host Species
Rabbit
Isotype
IgG
Conjugate/Modification
Unmodified
Recommended Dilution Ratio
WB 1:2000-1:10000
Formulation
PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
Purification
The antibody was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen.
Storage
-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration
1 mg/ml
Clonality
Polyclonal
Immunogen
--
Specificity
Endogenous
Gene Name
HMOX1 HO HO1
Protein Name
HO-1(Heme Oxygenase 1)
Other Name
Heme oxygenase 1 (HO-1) (EC 1.14.99.3)
Species
Human
Gene ID
3162
Uniprot
P09601,
Species
Mouse
Gene ID
15368
Uniprot
P14901,
Species
Rat
Gene ID
24451
Uniprot
P06762
Cellular Localization
Endoplasmic reticulum membrane
Tissue Expression
Expressed at higher levels in renal cancer tissue than in normal tissue (at protein level).
Signaling_pathway
Cellular Processes >> Cell growth and death >> Ferroptosis;Human Diseases >> Cancer: overview >> Pathways in cancer;Human Diseases >> Cancer: overview >> MicroRNAs in cancer;Human Diseases >> Cancer: specific types >> Hepatocellular carcinoma;Environmental Information Processing >> Signal transduction >> HIF-1 signaling pathway
Research Areas
>>Porphyrin metabolism; / >>Metabolic pathways; / >>HIF-1 signaling pathway; / >>Ferroptosis; / >>Mineral absorption; / >>Pathways in cancer; / >>MicroRNAs in cancer; / >>Chemical carcinogenesis - reactive oxygen species; / >>Hepatocellular carcinoma; / >>Fluid shear stress and atherosclerosis
Function
Catalytic activity:Heme + 3 AH(2) + 3 O(2) = biliverdin + Fe(2+) + CO + 3 A + 3 H(2)O.,Function:Heme oxygenase cleaves the heme ring at the alpha methene bridge to form biliverdin. Biliverdin is subsequently converted to bilirubin by biliverdin reductase. Under physiological conditions, the activity of heme oxygenase is highest in the spleen, where senescent erythrocytes are sequestrated and destroyed.,induction:Heme oxygenase 1 activity is highly inducible by its substrate heme and by various non-heme substances such as heavy metals, bromobenzene, endotoxin, oxidizing agents and UVA.,similarity:Belongs to the heme oxygenase family.,

Tech Support

ucallm

01

Documents

Datasheet, COA, SDS, and protocol files can be requested from technical support.

02

Contact Support

Emailinfo@mail.ucallm.com

Phone+(1)-866-986-9598

WeChat / IMUcallm-Tech

HoursMonday-Friday 09:00-18:00 CST

Request Technical Support
Keywords:Polyclonal antibodies