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In Vivo Models

Browse this article to obtain more content about In Vivo Models.

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3D Models

Three-dimensional models can more closely recapitulate the spatial architecture of real tissues and can further integrate tumor cells, stromal cells, and immune cells, making them useful for studying tumor–immune interactions and evaluating immunotherapies.

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Co-culture

Tumor–immune cell co-culture models are a type of in vitro research model in which tumor cells and immune cells are cultured together to simulate the interactions between tumor cells and immune cells within the tumor microenvironment (TME).

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2D Cell Culture

Two-dimensional cell culture (2D Cell Culture) is one of the most fundamental and widely used in vitro models in immune cell research.

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Immune Cells and Tumor Microenvironment

The Tumor Microenvironment (TME) is a complex microenvironment composed of tumor cells, immune cells, Cancer-Associated Fibroblasts (CAFs), endothelial cells, extracellular matrix (ECM), and various cytokines and chemokines.

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Immune Cells and Cell Death

Cell death is not only a fundamental biological process responsible for maintaining tissue homeostasis and eliminating abnormal cells, but also an important link connecting intracellular stress, innate immunity, adaptive immunity, and tumor immunity.

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Immunotherapy

Immunotherapy is an important therapeutic strategy that treats diseases by activating, enhancing, redirecting, or relieving immune suppression.

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Infection and Inflammation

Following infection, the host first recognizes pathogen-associated molecular patterns (PAMPs) through the innate immune system and rapidly initiates immune defense mechanisms.

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Autoimmune Diseases

Autoimmune diseases are a group of disorders caused by abnormal immune responses against self-antigens, resulting in persistent inflammation and tissue damage.

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